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Completed

NCT Number: NCT07807657

Asymmetry Index From Photogrammetric Analysis

We propose a transversal observational study, to be performed on three-dimensional images acquired through photogrammetry of patients who will undergo orthodontic treatments. The aim of our research consists in the evaluation of facial asymmetry through a graph built on three degrees of Asymmetry Index (symmetry, slight asymmetry, asymmetry) in an Italian population that meets the criteria of absence of craniofacial deformities and that has not undergone surgery or orthodontic treatment.

For the analysis, images acquired via photogrammetry are used, then analyzed with the Geomagic Control 2014 program (64 bit).

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondazione Policlinico Gemelli IRCCS

Rome, 00168, Italy

About this study

Facial symmetry is considered one of the most significant factors in the perception of facial attractiveness. A slight degree of asymmetry is common in the human face and often does not require any treatment], as it is camouflaged by the presence of soft tissue, dental compensation or change in head posture .

However, the problem of asymmetry is difficult to manage for the dentist and, in particular, for the orthodontist. In fact, there are many etiological factors related to the development of facial asymmetry and asymmetries that share the same etiology can have different characteristics, as they are influenced by other factors, such as individual growth and compensation.

In fact, at the very moment of the physical examination, it is often not easy to identify the degree of severity of the patient's facial asymmetry. During the clinical examination, dental and skeletal asymmetry can be evaluated: facial asymmetry can be investigated by simple observation of the patient .

However, the aid of instrumental radiological examinations has always been considered the choice for determining the degree of asymmetry.

Orthopantomography is one of the first diagnostic tests that is performed, thanks to its low cost and low radiation dose.

The analysis of teleradiographs appears to be, however, the most reliable and most used means over time for the diagnosis of asymmetry. Traditional radiographic examinations, however, (PA and SV projection teleradiographs) have limitations in determining the diagnosis of asymmetry as they make a three-dimensional image two-dimensional, which can lead to distortions and errors in image projection .

The development of computed tomography (CT), cone beam (CBCT) and stereophotogrammetry have brought about a new era in the field of asymmetry diagnosis . 3D images have greatly reduced the magnification and projection errors common in conventional radiographs while providing an important aid in the evaluation of asymmetry. They can also offer accurate and more detailed information for diagnosis and treatment planning by allowing quantitative measurements and comparisons between the right and left sides of the face.

The introduction of non-invasive three-dimensional image acquisition via photogrammetry has made it possible to view the patient's face from different angles providing the possibility to perform accurate measurements of lengths, areas, angles and volumes.

Although the nature of the asymmetry is complex and the characteristics are different, there have been some attempts to create a systematic classification of facial asymmetry.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • between the ages of 18 and 40;
  • absence of craniofacial deformities.

Exclusion criteria

  • must not have undergone orthodontic treatments in the past;
  • must not have performed orthognathic surgery;
  • must not have suffered facial trauma.

Treatment and study plan

stereophotogrammetry

Other

acquisition of a stereophotographic image on which to make 3D measurements

Primary outcomes

  1. Asymmetry index

    Time frame: 3 years

    construction of a facial asymmetry index useful for distinguishing patients who can be treated with orthodontics from those who need maxillofacial surgery

Sponsors and collaborators

Lead sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Other

Registry information

Official study title

ASYMMETRY INDEX FOR THE PHOTOGRAMMETRIC EVALUATION OF THE DEGREE OF FACIAL ASYMMETRY

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
Sep 8, 2026
Registry last updated
Sep 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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