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NCT Number: NCT07806565

Naloxone for In-Hospital Cardiac Arrest

The goal of this clinical trial is to learn if the drug naloxone in addition to cardiopulmonary resuscitation improves outcomes of in-hospital cardiac arrets. The main questions it aims to answer are:

Does naloxone improve survival after the cardiac arrest? Does naloxone improve functional outcome in survivors of cardiac arrest? Does naloxone improve health related quality of life after the cardiac arrest? How common are adverse reactions to naloxone when administered during cardiopulmonary resuscitation.

Researchers will compare naloxone to a placebo (a look-alike substance that contains no drug) to see if naloxone works during cardiac arrest.

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Key information

Conditions

Heart Arrest Cardiovascular Diseases Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • In-Hospital Cardiac Arrest
  • Age ≥ 18 years
  • Received at least one dose of adrenaline during CPR

Exclusion criteria

  • "Do-not-resuscitate"-order
  • Known/suspected pregnancy
  • Known objection by the patient to participate in the trial
  • Previous inclusion in the trial

Treatment and study plan

naloxone

Drug

2 mg naloxone administered intravenously or intraosseously

Placebo

Drug

0.9% saline administered intravenously or intraosseously

Primary outcomes

  1. 30-day survival

    Time frame: 30 days after the cardiac arrest

    proportion of patients alive

Study contacts

Contact information is provided by the study sponsor or research team.

Anna Lybeck, MD PhD

CONTACT

[email protected]

0771-11 14 44

Sponsors and collaborators

Lead sponsor

Region Skane

Other

Collaborators

  • Clinical Studies Sweden - Forum South
  • Copenhagen Trial Unit, Center for Clinical Intervention Research
  • Lund University

Registry information

Acronym: naloxone-IHCA

Important dates

Study start
2027
Primary completion
2030
Study completion
2031
First posted
Sep 8, 2026
Registry last updated
Sep 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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