Dexmedetomidine for Sedation in Patients Requiring Mechanical Ventilation is Associated With a Lower Incidence of Delirium

This retrospective cohort study will include 412 adults mechanically ventilated >24 hours in intensive care unit in sohag university hospital between 2024 and 2026). Participants will be assigned to either, EGDS group ( equal to 208 ) or conventional sedation group (equal to 204 ). The main endpoint will be measured is the incidence of delirium in ICU , measured by the Confusion Assessment Method for the ICU (CAM-ICU). Secondary endpoints will be the number of the days free from ventilation at 28 days (VFDs), ICU length of stay (LOS) in the ICU, and the death during hospitalization.

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Key information

Conditions

Mechanical Ventilation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Consecutive adult patients aged 18 years or older who required invasive mechanical ventilation for more than 24 hours.

Exclusion criteria

Neurological primary admission such as stroke or traumatic brain injury.
Active seizures or alcohol withdrawal at admission.
Prior dementia or severe cognitive impairment.
Mechanical ventilation <24 hours.
Death within 48 hours of admission.
Missing essential sedation or delirium data.

Treatment and study plan

Primary outcomes

occurrence of delirium during the ICU admission

Time frame: Within 12 hours of intubation

main end point: occurrence of delirium during the ICU admission , defined as at least one positive CAM-ICU assessment.

Secondary outcomes

Number of Ventilator-free days (VFDs)

Time frame: 6 months
duration of ICU stay (LOS)

Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Dexmedetomidine for Sedation in Patients Requiring Mechanical Ventilation is Associated With a Lower Incidence of Delirium : A Retrospective Study

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2027
First posted: Sep 8, 2026
Registry last updated: Sep 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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