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NCT Number: NCT07806162

Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection.

The invistigators hypothesized that a protocolized OFA technique would lower the occurance of PONV in patients undergoing thoracoscopic lung surgery compared to standard opioid-based anaesthesia.

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Key information

Conditions

PONV Nausea Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Postoperative Nausea and Vomiting Signs and Symptoms Signs and Symptoms, Digestive Vomiting

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-

  • Eligible participants were adults (18-80 years).
  • Prepared for elective thoracoscopic lobectomy or segmentectomy for lung cancer under general anaesthesia

Exclusion criteria

  • Contraindication to any study drug (e.g., heart block, severe liver disease, allergy).
  • Chronic opioid use (>30 MME/day for >3 months).
  • Patients with renal impairment (e GFR <30 mL/min).
  • Pregnancy.
  • Inability to comprehend pain scales.

Treatment and study plan

Opioid Free Anaesthesia

Drug

The OFA group protocol consists of a combination of intravenous lidocaine, ketamine, dexmedetomidine, and propofol TIVA.

conventential opioid-based anaesthesia (OBA,

Drug

The OBA group protocol consists of balanced anaesthesia with fentanyl plus sevoflurane.

Primary outcomes

  1. the occurrence of PONV during the initial 24 hours

    Time frame: 24 hours

Secondary outcomes

  1. total opioid consumption over 24 hour (expressed as morphine milligram equivalents.

    Time frame: 24 hours

  2. pain intensity scores (numerical rating scale NRS 0-10)

    Time frame: 24 hours

  3. recovery quality (QoR-15 score)

    Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Comparison Between Opioid-Free Anaesthesia Versus Opioid Based Anesthesia in Reduction Postoperative Nausea and Vomiting (PONV)After Thoracoscopic Lung Resection. A Prospective Randomised Controlled Trial)

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 8, 2026
Registry last updated
Sep 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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