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NCT Number: NCT07805005

NLR and PLR in H. Pylori-Associated Gastritis

This cross-sectional study aims to evaluate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as inflammatory markers in patients with Helicobacter pylori-associated gastritis at Assiut University Hospitals.

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Key information

Conditions

Helicobacter Pylori Infection Digestive System Diseases Dyspepsia Gastritis Gastroenteritis Gastrointestinal Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Digestive Stomach Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Helicobacter pylori is a major cause of gastritis and is associated with chronic gastric inflammation. Systemic inflammatory markers derived from complete blood count, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been proposed as simple and inexpensive indicators of inflammation.

This cross-sectional study will include adult patients with dyspepsia undergoing testing for H. pylori by endoscopy and biopsy at Assiut University Hospitals. Complete blood count will be performed to calculate NLR and PLR. The study will assess the association of these ratios with the presence of H. pylori infection and the severity of gastritis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • - Age 18 years or older
  • Patients with dyspepsia
  • Patients undergoing endoscopy and biopsy for H. pylori testing
  • Willingness to provide informed consent

Exclusion criteria

  • - Hematological diseases
  • Active infection other than H. pylori
  • Chronic inflammatory or autoimmune diseases
  • Malignancy
  • Recent use of steroids or immunosuppressive drugs
  • Recent acute bleeding

Treatment and study plan

Primary outcomes

  1. Neutrophil-to-lymphocyte ratio (NLR) in H. pylori-associated gastritis

    Time frame: Baseline

    Neutrophil-to-lymphocyte ratio calculated from complete blood count in patients with confirmed H. pylori-associated gastritis compared with patients without H. pylori infection.

Secondary outcomes

  1. Platelet-to-lymphocyte ratio (PLR)

    Time frame: Baseline

    Platelet-to-lymphocyte ratio calculated from complete blood count in patients with and without H. pylori infection.

  2. Diagnostic performance of NLR

    Time frame: Baseline

    Sensitivity, specificity, and optimal cutoff value of NLR for predicting H. pylori infection using receiver operating characteristic (ROC) curve analysis.

  3. Diagnostic performance of PLR

    Time frame: Baseline

    Sensitivity, specificity, and optimal cutoff value of PLR for predicting H. pylori infection using ROC curve analysis.

  4. Correlation of NLR and PLR with severity of gastritis

    Time frame: Baseline

    Correlation coefficient between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values and the severity grade of gastritis based on endoscopic and/or histopathological findings, using Spearman or Pearson correlation as appropriate.

Study contacts

Contact information is provided by the study sponsor or research team.

Hadeer A Mohamed, Resident

CONTACT

[email protected]

+20 11 25445957

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Helicobacter Pylori-Associated Gastritis

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Sep 4, 2026
Registry last updated
Sep 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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