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NCT Number: NCT07804446

Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will:

1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

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Key information

Conditions

Osteoarthitis Agnosia Arthritis Joint Diseases Musculoskeletal Diseases Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Osteoarthritic Knee Pain Osteoarthritis Osteoarthritis (OA) Osteoarthritis (OA) of the Knee Osteoarthritis in the Knee Osteoarthritis, Knee Pain Pathological Conditions, Signs and Symptoms Perceptual Disorders Rheumatic Diseases Signs and Symptoms

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Bolingbrook Clinic, Bolingbrook, Illinois, United States

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 40
  • Clinical diagnosis of knee OA with predominant medial compartment symptoms
  • Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
  • Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
  • Able to provide informed consent
  • Able to complete phone, email, or MyChart follow-ups in English

Exclusion criteria

  • Predominant lateral compartment OA or patellofemoral-only OA
  • Inflammatory arthritis (RA, gout flare, etc.)
  • Suspected or confirmed joint infection or overlying cellulitis
  • Prior knee arthroplasty on the index knee
  • Planned surgery for index knee within 12-week follow-up
  • Inability to complete follow-up assessments
  • Other clinician-determined contraindication to CSI

Treatment and study plan

Anteromedial Injection

Procedure

If randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.

Anterolateral Injection

Procedure

If randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.

Primary outcomes

  1. Numeric Pain Rating Scale

    Time frame: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection

    This survey asks patients to rate their pain on a scale from 0 to 10.

  2. Knee Osteoarthritis and Outcome Score-Joint Replacement

    Time frame: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection

    This standardized survey asks patients to describe the impact of their knee stiffness and pain on daily tasks.

Secondary outcomes

  1. Institutional Survey on Satisfaction with Injection

    Time frame: 2 weeks, 6 weeks, and 12 weeks post-injection

    This survey asks patients to rate their satisfaction with their corticosteroid injection on a scale from 0 to 10.

  2. Patient Global Impression of Change

    Time frame: 2 weeks, 6 weeks, and 12 weeks post-injection

    This survey asks patients to rate their overall health status on a scale from 1 to 7.

Study contacts

Contact information is provided by the study sponsor or research team.

Malik J Scott, B.A.

CONTACT

[email protected]

773-834-3531

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

  • AdventHealth

Registry information

Official study title

Does Injection Site (Anteromedial vs Anterolateral) Affect Pain Relief After Intra-Articular Corticosteroid Injection in Moderate-to-Severe Medial Knee Osteoarthritis?

Acronym: Medial OA CSI

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 4, 2026
Registry last updated
Sep 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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