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OpenTrials
Enrolling by invitation

NCT Number: NCT07804095

AI-Supported Care Engagement for Next-step Delivery - Medicare Advantage

ASCEND-MA is an embedded, health-services study of at-risk Medicare Advantage members attributed to Intermountain Health in Utah. Participants are quasi-randomized based on their medical-record-number parity to either AI-supported, nurse-reviewed proactive care navigation or usual care. The study will evaluate whether the program changes cumulative payor-paid healthcare spending over 12 months.

Enrolling by invitation

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Intermountain Health - ASCEND-MA Statewide Cohort

Murray, Utah, 84107, United States

About this study

An additional ancillary, separately consented consumer-experience sub-study will sample roughly 45 intervention-arm participants for surveys and interviews about the acceptability, burden, and perceived usefulness of the care-navigation workflow.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

•.Enrolled in an eligible Medicare Advantage plan and attributed to Intermountain Health in Utah.

  • Continuous Medicare Advantage enrollment for at least 6 months before the index date.
  • PRM Rising-Risk score (an internally derived prediction model) of at least 0.70 and Current-Risk score below 0.95 at index
  • Predicted year-over-year cost increase of at least 30%.
  • At least one targeted chronic condition: diabetes mellitus, heart failure, chronic obstructive pulmonary disease, chronic kidney disease, hypertension, or hyperlipidemia.

Exclusion criteria

  • Hospice enrollment at index.
  • End-stage renal disease requiring chronic dialysis at index.
  • Active oncology treatment at index.
  • Long-term institutional residence, including skilled-nursing-facility residence, at index.
  • Primary language cannot be supported through patient-directed outreach and no feasible alternative care-team communication pathway is available.

Treatment and study plan

AI-Supported Rising-Risk Care Navigation

Other

AI-supported proactive care navigation involves the generation of guideline-informed candidate care-navigation actions from protocol-authorized structured data, human-in-the-loop review by a nurse, and then delivery of the approved suggestion through existing care-management or clinical workflows. The nurse may accept, modify, reroute, or reject each candidate before participant outreach or care-team routing. Reassessment is planned approximately every 90 days and may change intervention delivery, but not assigned-group membership.

Primary outcomes

  1. Cumulative payer-paid health care spending per participant

    Time frame: 1 year

    Mean cumulative payer-paid health care spending (in U.S. dollars) recorded in claims per participant.

Secondary outcomes

  1. Rate of All-Cause Acute-Care Episodes

    Time frame: 1 year

    Inpatient admissions, emergency department visits, and observation stays will be combined into acute-care episodes, with related encounters counted once.

Other outcomes

  1. Analyses of Condition (Heart Failure, Diabetes, Chronic Obstructive Pulmonary Disease, Chronic Kidney Disease) specific endpoints

    Time frame: 1 year

    Exploratory analyses will assess prespecified condition-specific care-process and utilization measures in heart failure, diabetes, chronic obstructive pulmonary disease, and chronic kidney disease.

Sponsors and collaborators

Lead sponsor

Intermountain Health Care, Inc.

Other

Registry information

Official study title

AI-Supported Care Engagement for Next-step Delivery - Medicare Advantage (ASCEND-MA)

Acronym: ASCEND-MA

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Sep 4, 2026
Registry last updated
Sep 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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