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NCT Number: NCT07803536

Effect of Late Ripcord Removal From Glaucoma Drainage Device

This is a research study to find out if removing the ripcord from a glaucoma drainage device more than 3 months after it has been placed has any effect on intraocular pressure. Participation in research studies is voluntary.

The ripcord will be removed at a routine glaucoma care visit and intraocular pressure will be measured before removal, 30 minutes following, and at 1 week, 6 weeks and 3-month intervals during regular clinic visits.

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Key information

Conditions

GLAUCOMA 1, OPEN ANGLE, D (Disorder) Eye Diseases Glaucoma Ocular Hypertension

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Duke University Eye Center

Durham, North Carolina, 27705, United States

Location contact

Agnes C Owete, MD

SUB_INVESTIGATOR

Jonathan Shepherd

CONTACT

[email protected]

919-681-3937

Leon W Herndon, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > 18 years
  • Placement of Ahmed Clear Path or Baervelt drainage device with ripcord > 3 months
  • Diagnosis of Glaucoma, under active management at Duke Eye Center Glaucoma Clinic
  • Ripcord suture still in place and accessible for removal
  • Able to provide written informed consent
  • IOP > 10 mm Hg

Exclusion criteria

  • Active ocular infection or conjunctivitis in either eye
  • Inability to undergo ripcord removal procedure
  • Scheduled for further glaucoma surgery

Treatment and study plan

Ripcord removal

Procedure

Patients who have had a ripcord in place for greater than 3 months postoperatively will undergo ripcord removal in the office.

Primary outcomes

  1. Change in intraocular pressure (IOP)

    Time frame: Immediately after, 1 week, 6 weeks and 3-month intervals

    Change in intraocular pressure

Secondary outcomes

  1. Change in Drop Burden

    Time frame: 1 week, 6 week and 3 month interval

    Measured by the number of participants who miss drop doses

Study contacts

Contact information is provided by the study sponsor or research team.

Jonathan Shepherd

CONTACT

[email protected]

(919) 681-3937

Sponsors and collaborators

Lead sponsor

Duke University

Other

Registry information

Official study title

Prospective, Single-arm Interventional Study to Determine Effect of Late Ripcord Removal From Glaucoma Drainage Device

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Sep 3, 2026
Registry last updated
Sep 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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