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NCT Number: NCT07803510

Presurgical Illustration and Psychological Stress in Mandibular Third Molar Surgery

The aim of this clinical trial is to evaluate the influence of presurgical patient's diagrammatic illustration of mandibular third molar (Wisdom tooth) surgery on degrees of psychological stress.

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Key information

Age range

18 year–32 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Oral and Maxillofacial Surgery, Faculty of Oral and Dental Medicine, Delta University for Science and Technology

Al Mansurah, Addakahlyia, 35516, Egypt

Location status: Recruiting

Location contact

Mohammad Abdelhamid, PhD

CONTACT

[email protected]

00201002285659

Mohammad Abdelhamid, PhD

PRINCIPAL_INVESTIGATOR

About this study

Psychological stress is a common factor accompanied with surgeries in most situations, and mandibular third molar (Wisdom tooth (WT)) surgery couldn't be an exception. Saliva was proven as a valid carrier that could be used to track the levels of cortisol representing the degree of patient's provoked stress. Patient orientation and presurgical diagrammatic illustration of the steps of WT surgery are very important aspects for patient preparation, yet, may be potential stress triggers as well.

This study aims to figure out if patients are exposed to illustrations that shows the mandibular third molar surgery before having the surgery would aggravate their stress or may relieve it considering orientation and relative absence of fear of unknown.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy patients (American Society of Anesthesiologists Class I),
  • Patients demanding extraction of their mandibular third molar,
  • Mandibular third molars requiring flap raising, bone removal, coronal and radicular sectioning (Modified Parant Scale Class IV),
  • Patients accepting their saliva sampling prior to and after surgery.

Exclusion criteria

  • Acutely painful mandibular third molars on clinical examination,
  • Pericoronal and/or active periapical and/or active periodontal pathologies on clinical and radiographic examinations,
  • Patients using steroids,
  • Psychiatric patients,
  • Smokers,
  • Pregnant patients, and/or those observing their menstruation,
  • Patients with conditions of altered cortisol secretion (such as Addison's disease, Cushing's syndrome, and congenital adrenal hyperplasia),
  • Patients with altered secretion of saliva (such as due to using atropine, calcium channel blockers, antidepressants, antihistamines, Sjogren's syndrome, and radiotherapy).
  • Patients who are overtly anxious about dental treatment (scoring >19 on the Modified Dental Anxiety Scale).

Treatment and study plan

Presurgical Diagrammatic Illustration for Mandibular Third Molar Surgery

Other

The handling surgeon will show the patient (in the study group) a diagrammatic illustration for surgical steps of mandibular third molar extraction. This diagrammatic illustration includes flap raising, bone guttering, coronal and radicular tooth sectioning, and flap closure.

Primary outcomes

  1. Salivary Cortisol Level (in ng/mL)

    Time frame: 45 minutes before surgery, and 30 minutes after surgery.

    Amount of salivary cortisol found in patients' saliva is considered directly proportional to degree of psychological stress.

Secondary outcomes

  1. Duration of Surgery (in minutes)

    Time frame: Same time of surgery

    Time taken for each surgery will be recorded starting from flap incision to end of last closing suture knot.

Study contacts

Contact information is provided by the study sponsor or research team.

Mohammad Abdelhamid, PhD

CONTACT

[email protected]

00201002285659

Sponsors and collaborators

Lead sponsor

Delta University for Science and Technology

Other

Registry information

Official study title

Role of Presurgical Illustration on Patients' Psychological Stress Monitored by Salivary Cortisol in Mandibular Third Molar Surgery

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 3, 2026
Registry last updated
Sep 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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