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NCT Number: NCT07803315

Hyperspectral Imaging in Robot-Assisted Partial Nephrectomy

The goal of this prospective observational study is to learn about the use of a novel imaging technique called hyperspectral imaging in adult participants who are having surgery for removing a tumor from their kidney. Hyperspectral imaging works by shining light on a structure (in this case, the kidney tissue with the tumor) and capturing how it reflects hundreds of very narrow color bands, including ones the human eye can't see. These patterns depend on the composition of the tissue and for example how well blood is flowing through the tissue. By studying these patterns, the investigators want to understand if this technique can be helpful for the surgery where only the part of the kidney with the tumor is removed.

The main questions it aims to answer are:

* Can hyperspectral imaging show the areas of blood flow in the kidney during surgery? * Is there a connection between the detected patterns of light and the type of kidney tumor?

The imaging will happen during the already planned surgery and the participant does not need to undergo any additional tests.

Recruiting

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Key information

Conditions

Kidney Neoplasm Adenocarcinoma Carcinoma Carcinoma, Renal Cell Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Neoplasms Male Urogenital Diseases Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Renal Mass up to 7cm Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Leipzig

Leipzig, 04103, Germany

Location status: Recruiting

Location contact

Clara Steiner, Dr.

SUB_INVESTIGATOR

Doreen Trebst, Dr.

CONTACT

[email protected]

+49 3419717610

Doreen Trebst, Dr.

PRINCIPAL_INVESTIGATOR

Jens-Uwe Stolzenburg, Prof. Dr.

PRINCIPAL_INVESTIGATOR

Jens-Uwe Stolzenburg, Professor Dr.

CONTACT

[email protected]

+49 3419717600

Sigrun Holze, Dr.

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with a kidney tumor ≤7cm
  • planned robot-assisted partial nephrectomy
  • age ≥ 18 years

Exclusion criteria

  • patients with a previous surgery on the affected kidney
  • patients with a fully intrarenal/endophytic tumor without an exophytic component
  • previous malignancy with ongoing or planned nephrotoxic chemotherapy
  • current immunosuppression (e.g., organ transplantation, leukemia)
  • pregnancy, lactation, or women who wish to have children
  • inability to give informed consent

Treatment and study plan

Primary outcomes

  1. Correlation of hyperspectral imaging (HSI) data with clamping technique during robot-assisted partial nephrectomy (RAPN)

    Time frame: day of surgery

  2. Correlation of HSI data with histopathological report

    Time frame: day of surgery

Secondary outcomes

  1. Correlation of HSI data with demographic parameters

    Time frame: day of surgery

  2. Correlation of HSI data and respective clamping technique with postoperative kidney function

    Time frame: from the day of surgery until discharge (up to 6 days)

Study contacts

Contact information is provided by the study sponsor or research team.

Doreen Trebst, Dr.

CONTACT

[email protected]

+49 3419717610

Jens-Uwe Stolzenburg, Professor Dr.

CONTACT

[email protected]

+49 3419717600

Sponsors and collaborators

Lead sponsor

University of Leipzig

Other

Registry information

Official study title

Perfusion Mapping and Tissue Characterization Using Hyperspectral Imaging in Robot-Assisted Partial Nephrectomy

Acronym: HSI-Renal

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Sep 3, 2026
Registry last updated
Sep 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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