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Completed

NCT Number: NCT07802613

ALDH2 rs671, Alcohol Use, and Health Education in University Students

Alcohol intolerance is common in East Asian populations and is strongly influenced by the rs671 variant in the ALDH2 gene. This study examined the associations of ALDH2 genotype with drinking behavior and alcohol-related reactions among Taiwanese university students. Participants with previous alcohol exposure underwent rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance and related health risks. Drinking behavior, knowledge, and attitudes were assessed before and one month after the intervention. The study also evaluated whether facial flushing and rapid heartbeat could help identify ALDH2 deficiency. Changes over the one-month period were evaluated overall and by genotype group.

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Key information

Conditions

Alcohol Intolerance Adherence Interventions Alcohol Drinking Alcohol Drinking in College Aldehyde Dehydrogenase-2 (ALDH2) Deficiency Behavior Drinking Behavior Health Behavior Health Education Medication Adherence Patient Acceptance of Health Care Patient Compliance Treatment Adherence and Compliance

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan University

Taipei, 100, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Currently enrolled as a student at National Taiwan University
  • Aged 18 to 65 years

Exclusion criteria

  • None

Treatment and study plan

Individual ALDH2 Genotype Feedback

Behavioral

Participants underwent ALDH2 rs671 genotyping and received an individual report indicating their rs671 genotype (GG, GA, or AA) and corresponding ALDH2 metabolic status. No individualized health education was provided based on genotype.

Standardized Alcohol Health Education

Behavioral

All participants received the same standardized health education materials concerning alcohol metabolism, symptoms of alcohol intolerance, and health risks associated with alcohol use and ALDH2 deficiency. The educational content was not individualized according to genotype.

Primary outcomes

  1. Change From Baseline in Drinking Frequency at One Month

    Time frame: Baseline to one month after receipt of genotype feedback and health education

    Drinking frequency was assessed using a study-specific questionnaire with ordinal response categories reflecting the number of drinking occasions per month. The change score was calculated from the baseline and one-month responses according to the prespecified questionnaire coding.

  2. Change From Baseline in Alcohol Consumption per Drinking Occasion at One Month

    Time frame: Baseline to one month after receipt of genotype feedback and health education

    Alcohol consumption per drinking occasion was assessed using ordinal categories of 1-2, 3-4, or 5 or more alcohol units. One alcohol unit was calculated as [beverage volume (mL) × alcohol by volume (%)]/1000. The change score was calculated from the baseline and one-month responses.

  3. Change From Baseline in Drinking Attitude Score at One Month

    Time frame: Baseline to one month after receipt of genotype feedback and health education

    Attitudes toward drinking were assessed using six study-specific statements rated on a five-point Likert scale from strongly disagree to strongly agree. Items were coded according to the prespecified scoring method and summed to produce a total attitude score, with higher scores indicating healthier attitudes toward alcohol use.

  4. Change From Baseline in Alcohol Intolerance Knowledge Score at One Month

    Time frame: Baseline to one month after receipt of genotype feedback and health education

    Knowledge was assessed using a study-specific questionnaire covering alcohol metabolism, symptoms of alcohol intolerance, related health risks, diagnosis, treatment, and prevalence. The total score was calculated from correct responses, with higher scores indicating greater knowledge.

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

Investigation of the Relationship Between rs671 Polymorphism and Attitudes and Behaviors Toward Drinking and Effectiveness of Health Education

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Sep 3, 2026
Registry last updated
Sep 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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