Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07802574

Effects of Interrupting Prolonged Sitting With Different Standing Intervals on Vascular Health in Women

The goal of this clinical trial is to examine the effects of interrupting prolonged sitting with different standing intervals on vascular health in healthy women aged 18-45 years. The main questions it aims to answer are:

Does interrupting prolonged sitting with short standing intervals (10 minutes every hour) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)? Does interrupting prolonged sitting with prolonged intermittent standing intervals (30 minutes every hour divided into three 10-minute standing bouts) improve blood pressure and pulse wave velocity more than prolonged continuous standing intervals (30 minutes every hour)?

The researcher will compare three different sitting interruption conditions to evaluate their effects on vascular health outcomes:

Standing for 10 minutes every hour. Continuous standing for 30 minutes every hour. Intermittent standing for 30 minutes every hour divided into three 10-minute standing bouts.

Participants will:

Attend three experimental sessions in random order separated by at least 7 days.

Complete 3 hours of sitting with different standing interruption protocols. Undergo measurements of blood pressure, pulse wave velocity, and heart rate before sitting and after each hour of the experiment.

Undergo height, weight, and body mass index measurements.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Prolonged Sitting Behavior Sedentary Behavior Vascular Health

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

King Saud University

Riyadh, Saudi Arabia

Location status: Recruiting

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Female participants aged 18-45 years. Healthy individuals with normal blood pressure levels (systolic blood pressure <130 mmHg and diastolic blood pressure <80 mmHg).

Body mass index (BMI) less than 30 kg/m². Ability to stand without support. No history of cardiovascular disease or chronic diseases that may affect study outcomes.

Exclusion criteria

Pregnancy or breastfeeding. Back injuries preventing prolonged sitting. Use of medications that may affect cardiovascular responses, including antihypertensive, antidiabetic, antidepressant, or hormonal medications.

Presence of chronic diseases or cardiovascular conditions affecting vascular health.

-

Treatment and study plan

Short Standing Interval

Behavioral

Participants will interrupt prolonged sitting with 10 minutes of standing every hour during 3 hours of sitting.

Continuous Standing Interval

Behavioral

Participants will interrupt prolonged sitting with 30 continuous minutes of standing every hour during 3 hours of sitting.

Intermittent Standing Interval

Behavioral

Participants will interrupt prolonged sitting with 30 minutes of standing every hour divided into three 10-minute standing bouts during 3 hours of sitting.

Primary outcomes

  1. Blood Pressure

    Time frame: Baseline, 1 hour, 2 hours, and 3 hours

    Systolic and diastolic blood pressure will be measured before sitting and after each hour during the experimental sessions.

  2. Pulse Wave Velocity

    Time frame: Baseline, 1 hour, 2 hours, and 3 hours

  3. Heart Rate

    Time frame: Baseline, 1 hour, 2 hours, and 3 hours

Study contacts

Contact information is provided by the study sponsor or research team.

Bushra k Alharbi

CONTACT

[email protected]

+966556913301

Sponsors and collaborators

Lead sponsor

King Saud University

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 3, 2026
Registry last updated
Sep 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.