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Completed

NCT Number: NCT07801924

Evaluation of the Effectiveness of Oral Ozonized Oil Supplementation in Elite Athletes

Ozonized oil has anti-inflammatory and antioxidant properties, but its effects on athletic performance remain unclear. This study evaluated whether daily ozonized oil supplementation, combined with training, influences aerobic capacity, anaerobic power, maximal strength, and muscular endurance in elite rugby players over six months

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Key information

Conditions

Recovery Methods Muscular Strength Endurance

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Stadio del Rugby, Avezzano, AQ, Italy

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inclusion criteria were age ≥18

Exclusion criteria

  • NA

Treatment and study plan

Ozonized Oil

Dietary Supplement

, the present study aimed to investigate the potential effects of daily oral supplementation with ozonized oil (O3ZONE Sport®) (produced for O3 ZONE LIMITED, Acquaviva, RSM) on physical performance outcomes - aerobic capacity, maximal strength, muscular endurance, and functional fitness - in elite rugby players over a six-month training period.

Primary outcomes

  1. The primary objective was to investigate the effects of ozonated oil administration on athletic performance and injury prevention in a group of 21 rugby athletes, divided into two groups: Experimental group (n=13) vs Control group (n=8)

    Time frame: 1 year

    Bruce test: which measures a subject's maximal oxygen consumption (VO2max). VO2max represents the maximum aerobic power, that is, the maximum amount of energy that can be synthesized by the aerobic mechanism in a unit of time.

Secondary outcomes

  1. The primary objective was to investigate the effects of ozonated oil administration on athletic performance and injury prevention in a group of 21 rugby athletes, divided into two groups: Experimental group (n=13) vs Control group (n=8)

    Time frame: 1 year

    Bronco test: is a 1,200 meter shuttle run designed to measure maximum aerobic speed (MAS) and endurance, primarily used in rugby. The test requires athletes to complete five sets of 20 meter, 40 meter, and 60meter shuttle runs, totalling 1,200 meters as fast as possible

  2. The primary objective was to investigate the effects of ozonated oil administration on athletic performance and injury prevention in a group of 21 rugby athletes, divided into two groups: Experimental group (n=13) vs Control group (n=8)

    Time frame: 1 year

    Leger Test:or multi-stage fitness test, requires running back and forth between two markers placed exactly 20 meters (65.6 feet) apart. The pace is set by audio beeps, with speeds increasing every minute (level), typically starting at 8.5 km/h and increasing by 0.5 km/h each level

Sponsors and collaborators

Lead sponsor

Universita degli Studi di Genova

Other

Registry information

Official study title

Evaluation of the Effects of Ozonated Oil Administration on Athletic Performance and Injury Prevention in Elite Athletes.

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 3, 2026
Registry last updated
Sep 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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