Correlation Between Dietary Patterns, Anthropometric Profiles, Genetic Profiles, and Biomarker Levels to Diabetes

Subject recruitment starts by sharing information across various platforms, such as WhatsApp groups and brochures distributed on the Trisakti University campus. Recruitment is open to students, faculty members, their families, and residents living near Trisakti University. Subsequently, an online meeting is held to outline the participation requirements, research stages, timeline, potential benefits, and possible side effects. A Google Form is then distributed for completion by meeting attendees who are genuinely interested in participating. Concurrently with subject recruitment, the eligibility of the catering service responsible for preparing the meals-specifically for the balanced diet and low-carb diet groups-is assessed.

The dietary regimen covers three main meals and two snacks daily. Meals are delivered three times a day: the first and second deliveries (covering breakfast, lunch, and morning/afternoon snacks) are made to the Trisakti University campus, while the third delivery is made directly to each subject's home. Deliveries take place on weekdays (Monday through Friday), with no deliveries on Saturdays or Sundays. A dietitian monitors dietary intake two to three times per week. Before the study begins, dietary education on balanced nutrition is provided to the balanced diet and control groups; the low-carb group also receives specific dietary education. This education ensures that subjects can maintain their prescribed diets on Saturdays and Sundays when no meals are delivered.

At the beginning of the study, all participants underwent fasting blood glucose testing to exclude those with fasting blood glucose levels >100 mg/dL. Subsequently, baseline laboratory tests were performed, and the experimental study commenced. The study was conducted over four weeks. Caloric intake is determined on an individual basis. A dietitian records and documents meal delivery daily.

At the conclusion of the study, a meeting will be held featuring a geneticist to explain the genetic test results, an internist to interpret the laboratory findings, and a nutrition specialist to provide dietary guidance based on the study results, followed by a health discussion related to the research topic.

Inclusion criteria

• Age between 18-59 years
• Participants must provide informed consent to participate in the study, which include dietary tracking, biometric testing, and adherence to the intervention program.
• Participants must be available for the full duration of the study (one months) and able to comply with the scheduled meal plans and testing appointments.

Exclusion criteria

• Individuals with history of type 1 and 2 diabetes, autoimmune, thyroid disease, which may affect carbohydrate metabolism.
• Individuals who have experienced major surgery in the past six months, as it might impact carbohydrate metabolism and the body's reaction to dietary modifications.
• Individuals with eating disorders, given the potential risks associated with dietary changes and the focus on food intake and biometrics.
• Individuals with allergies or intolerances to the ingredients used in the study's meal plans to prevent adverse health effects and ensure participant safety.
• Individuals currently participating in other clinical trials that could influence the outcomes of this study.