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Completed

NCT Number: NCT07797777

AI-Assisted Evaluation of Dental Anxiety in Children: A Machine Learning Approach

This observational study evaluated whether children's dental anxiety could be identified from their speech using artificial intelligence and machine learning methods. Children aged 8-12 years attending a pediatric dentistry clinic answered a set of short, standardized questions before receiving dental treatment. Their speech was recorded, and their dental anxiety was assessed during the same session using three established measures: the Children's Fear Survey Schedule-Dental Subscale, the Modified Child Dental Anxiety Scale, and the Face Image Scale.

Acoustic characteristics of the children's voices and linguistic characteristics of their spoken responses were analyzed together. Four machine learning algorithms were developed and evaluated to determine how accurately they could distinguish between children with lower and higher levels of dental anxiety. No treatment was assigned or modified as part of the study.

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Key information

Age range

8 year–12 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Marmara University Faculty of Dentistry

Istanbul, Maltepe, 34854, Turkey (Türkiye)

About this study

Dental anxiety can adversely affect a child's cooperation, treatment experience, and willingness to attend future dental appointments. Existing assessment methods primarily rely on self-report questionnaires, visual scales, and clinical observation. Artificial intelligence-based analysis of speech may provide an additional objective and non-invasive method for recognizing dental anxiety before treatment.

This prospective, cross-sectional observational study included children aged 8-12 years attending the Department of Pediatric Dentistry at Marmara University Faculty of Dentistry between September 2025 and February 2026. Data were collected within the natural workflow of an active pediatric dentistry clinic. The study did not assign participants to any treatment or alter their planned dental care.

Before dental treatment, each participant took part in a standardized 1-3-minute conversation conducted by the same researcher. The questions addressed everyday life, school, oral hygiene habits, previous dental experiences, and expectations regarding the planned dental visit. Speech was recorded using a standardized microphone position and recording protocol.

Immediately after the speech recording and before treatment, dental anxiety was assessed using the Children's Fear Survey Schedule-Dental Subscale, the Modified Child Dental Anxiety Scale, and the Face Image Scale. Scores from each measure were categorized into lower and higher anxiety levels using established thresholds and served as reference labels for machine learning model development.

All data were anonymized before analysis. The researchers' speech and prolonged silent segments were removed from the recordings, and the audio files were converted to a standardized format. Acoustic characteristics were extracted from the recordings using OpenSMILE. The spoken responses were transcribed and analyzed using natural language processing methods based on Whisper and a Turkish-language BERT model. Selected acoustic and linguistic features were combined into a multimodal dataset.

Random Forest, XGBoost, LightGBM, and CatBoost algorithms were trained and evaluated using five-fold cross-validation. Model performance was assessed using accuracy, sensitivity, specificity, precision, F1 score, the area under the receiver operating characteristic curve, predictive values, and confusion matrices. Agreement between model predictions was also evaluated. The primary objective was to identify the machine learning approach that most accurately and sensitively distinguished children with lower and higher dental anxiety levels.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

IInclusion Criteria:

  • Children aged 8-12 years
  • Attendance at the Department of Pediatric Dentistry, Marmara University -Faculty of Dentistry
  • Native Turkish speaker
  • Age-appropriate neuropsychological development
  • Ability to communicate, cooperate in the clinical setting, and understand and follow the study instructions
  • No chronic or systemic condition affecting speech production, respiratory function, or cognitive processes
  • Written informed consent provided by a parent or legal guardian

Exclusion criteria

  • Neurological, hearing, speech, or language disorder that could affect clinical communication or study assessments
  • Suspected or diagnosed neurodevelopmental disorder, including autism spectrum disorder or attention-deficit/hyperactivity disorder
  • Native language other than Turkish
  • Active pathology or history of surgery that could affect voice or speech quality, including resonance or phonation
  • Inability to provide sufficient verbal data, such as consistently giving single-word responses or leaving multiple questions unanswered

Treatment and study plan

Multimodal Speech-Based Dental Anxiety Assessment

Diagnostic Test

Participants completed a standardized 1-3-minute speech recording before dental treatment. Acoustic and linguistic characteristics of their speech were analyzed using artificial intelligence methods. During the same session, dental anxiety was assessed using the Children's Fear Survey Schedule-Dental Subscale, the Modified Child Dental Anxiety Scale, and the Face Image Scale. The assessment was conducted for research purposes and did not alter the participants' planned dental care.

Primary outcomes

  1. Classification Accuracy of the Multimodal Machine Learning Models

    Time frame: Day 1, during the single pre-treatment assessment

    Accuracy was defined as the proportion of participants correctly classified as having lower or higher dental anxiety. Random Forest, XGBoost, LightGBM, and CatBoost models were evaluated separately using reference classifications derived from the CFSS-DS, MCDAS, and FIS. Performance was assessed using five-fold cross-validation. Accuracy values range from 0 to 1, with higher values indicating better classification performance.

Secondary outcomes

  1. Sensitivity of the Multimodal Machine Learning Models

    Time frame: Day 1, during the single pre-treatment assessment

    Sensitivity was defined as the proportion of participants with higher dental anxiety who were correctly identified by each machine learning model. Sensitivity was calculated separately using the CFSS-DS, MCDAS, and FIS classifications as reference standards. Values range from 0 to 1, with higher values indicating better detection of children with higher dental anxiety.

Other outcomes

  1. F1 Score of the Multimodal Machine Learning Models

    Time frame: Day 1, during the single pre-treatment assessment

    The F1 score was calculated as the harmonic mean of precision and sensitivity to evaluate the balance between correctly identifying children with higher dental anxiety and limiting incorrect classifications. Macro and weighted F1 scores were calculated for each machine learning model using CFSS-DS, MCDAS, and FIS classifications as reference standards. Values range from 0 to 1, with higher values indicating better performance.

Sponsors and collaborators

Lead sponsor

Marmara University

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Sep 1, 2026
Registry last updated
Sep 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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