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OpenTrials
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NCT Number: NCT07797751

This Study Compares Two Noninvasive Dynamic Tools: Lung Ultrasound and Transthoracic Echocardiography Using LVOT VTI. It Aims to Measure the Sensitivity and Specificity of LUS in Guiding Fluid Resuscitation and Early Detection of Fluid Responsiveness and to Prevent Volume Overload

Reliability of the LVOT-VTI versus lung ultrasonography for early detection of fluid intolerance during fluid resuscitation of septic patients.

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Key information

About this study

Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral. To decrease the incidence of fluid accumulation syndrome.

  • To assess the feasibility and time required for each imaging modality in guiding fluid resuscitation.
  • Comparison of the time required for point-of-care lung ultrasound versus LVOT-VTI to guide fluid resuscitation decisions.

To assess the sensitivity and specificity of lung ultrasonography (B-Lines) in predicting fluid non responsiveness in septic shock patients

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients aged ≥ 18 years with septic shock.
  • Mean arterial pressure (MAP) <65 mmHg.
  • Need fluid resuscitation.

Exclusion criteria

  • Patient <18 years.
  • Refusal of patient or relative to participate in the study.
  • Other types of shock.
  • Morbid obesity.
  • Valvular heart disease including severe aortic and mitral stenosis) and (severe aortic and mitral regurgitation).

7.Patients with heart failure with preserved or reduced Ejection fraction. 8.Burn patients. 9.End stage renal disease with regular hemodialysis patient. 11.Patients with massive pleural effusion. 12. patients with septic cardiomyopathy. 13.patients with massive ascites. 14. patient on high positive end expiratory pressure or with acute respiratory distress syndrome (ARDS). 15. Patients with right ventricular failure & pulmonary hypertension. 16. Patients with pneumonia and interstitial lung diseases. 17. Ventilated patients. 18. Poor echo window patients.

Treatment and study plan

Primary outcomes

  1. Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral versus lung ultrasound

    Time frame: 12 hours

  2. Early detection of fluid accumulation syndrome in septic shock patients using velocity time integral ursus lung ultrasound.

    Time frame: 12 hours

Study contacts

Contact information is provided by the study sponsor or research team.

Mohamed ElSherbini El-Saedy, bachelor

CONTACT

[email protected]

+010037407868

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Comparing Lung Ultrasonography and Left Ventricular Outflow Tract Velocity Time Integral for Early Detection of Fluid Overload After Fluid Resuscitation in Septic Shock Patients

Acronym: lvotvti

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 1, 2026
Registry last updated
Sep 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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