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NCT Number: NCT07797049

Chia Seed Impact on Postprandial Glycemia and Appetite in Overweight Adults

Overweight and obesity affect nearly 2.5 billion adults worldwide and increase cardiometabolic risk. Postprandial glucose excursions are influenced by diet and inactivity and predict metabolic disorders, while South Asians, particularly Pakistanis, are more vulnerable due to genetic and lifestyle factors and processed diets. This study evaluates the impact of chia seed (Salvia hispanica L.) ingestion on postprandial glycemia and appetite in overweight adults, supporting UN Sustainable Development Goal 3 (Good Health and Well-being).

A randomized controlled crossover trial will be conducted among 30 overweight adults (BMI 25-29.9 kg/m²), aged 18-40 years. Participants will undergo control and intervention phases separated by a 14-day washout. The control beverage will contain 50 g glucose in 250 mL water, while the intervention beverage will contain the same beverage supplemented with 30 g chia seeds. Glucose response will be assessed using incremental area under the curve (iAUC) by the trapezoidal method, with appetite response also evaluated. Data will be analyzed using SPSS version 25; baseline characteristics will be presented as mean ± SD, and between-group differences will be assessed using a linear mixed model at p < 0.05. Chia seed ingestion is expected to reduce postprandial blood glucose and improve appetite control.

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Veterinary and Animal Sciences Lahore

Lahore, Punjab Province, 54000, Pakistan

Location contact

Kaniz Fatima Khalid Mir, Mphil Food and Nutrition

SUB_INVESTIGATOR

Univeristy of Veterinary and Animal Sciences

CONTACT

[email protected]

+92-42-99211374

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age: 18-40 years
  • BMI: 25-29.9 kg/m²
  • Male and female participants
  • Normoglycemic participants

Exclusion criteria

  • Pregnant
  • Smoking
  • Prediabetes/diabetes Medication use Chronic disease Supplementation

Treatment and study plan

Chia Seed (Salvia hispanica L.) Beverage

Dietary Supplement

Participants will consume a standardized beverage containing 50 g glucose dissolved in 250 mL water, without chia seeds or any other fiber-containing ingredient. This beverage will serve as the control condition for comparison with the chia seed-supplemented glucose beverage.

Other names: Glucose Beverage

Primary outcomes

  1. Postprandial Blood Glucose

    Time frame: 5 weeks

    Incremental area under the blood glucose curve (iAUC) will be calculated from capillary blood glucose concentrations measured using a portable blood glucose meter (glucometer) from finger-prick blood samples at baseline (0 minutes) and at 15, 30, 45, 60, 90, and 120 minutes following beverage consumption. The iAUC will be calculated using the trapezoidal method over the 120-minute postprandial period, with fasting baseline glucose concentration used as the reference. Areas below the baseline will not contribute to the iAUC. The iAUC will be expressed in mmol·min/L. A lower iAUC indicates a lower overall postprandial glycemic response over 120 minutes. The change in iAUC between the intervention (50 g glucose + 30 g chia seeds) and control (50 g glucose) beverages will be compared.

Secondary outcomes

  1. Appetite Response

    Time frame: 5 weeks

    Appetite will be assessed using 100-mm Visual Analog Scales for hunger, fullness, desire to eat, and prospective food consumption. Each scale ranges from 0 to 100 mm. For hunger, desire to eat, and prospective food consumption, 0 indicates the lowest intensity ("not at all"/"nothing at all") and 100 indicates the highest intensity ("extremely"/"an extremely large amount"); higher scores indicate greater appetite. For fullness, 0 indicates not at all full and 100 indicates extremely full; higher scores indicate greater fullness and better appetite suppression.

Study contacts

Contact information is provided by the study sponsor or research team.

Dr. Qaisar Raza, Phd

CONTACT

[email protected]

+923002479044

Kaniz Fatima Khalid Mir, Mphil Food and Nutrition

CONTACT

[email protected]

+923004629606

Sponsors and collaborators

Lead sponsor

University of Veterinary and Animal Sciences, Lahore - Pakistan

Other

Registry information

Official study title

Impact of Chia Seed (Salvia Hispanica L.) Ingestion on Postprandial Glycemia and Appetite in Overweight Adults: A Randomized Controlled Crossover Trial

Acronym: CHIA-PGA

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 1, 2026
Registry last updated
Sep 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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