Characterisation of MNEsic Involvement in Patients With Obesity.

The aim of the study is therefore to characterise memory impairment in a middle-aged population with obesity and to clarify the role of inflammation in obesity-related memory impairment.

The hypothesise that, as in an elderly population, neurological and memory impairment in a population of middle-aged obese individuals is heterogeneous, with varying levels of memory impairment characterised by neuropsychological test results. This heterogeneity in neuropsychological tests may be linked to markers of inflammation and brain imaging biomarkers identified previously in the litterature.

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Key information

Conditions

Obesity (Disorder) Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

30 year–50 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients suffering from obesity with a BMI between 30 and 45 kg/m²
Patients aged between 30 and 50 receiving educational care during the week at the CSO (Endocrinology, Diabetology and Nutrition Department) of the Bordeaux University Hospital.
Right-handed patients
Persons affiliated with or beneficiaries of a social security scheme.
Free, informed and express consent

Exclusion criteria

Patients currently undergoing treatment with neuroleptics or who have stopped treatment within the last 3 months.
Pregnant or breastfeeding patients
Known current or past neurological disease
Proven depressive syndrome treated
Patients with type 1 or type 2 diabetes
Uncontrolled dysthyroidism
MMS< 25
Patients with proven genetic obesity
Contraindication to MRI
Chronic use of NSAIDs or corticosteroids
Loss of 5% of body weight in the 3 months prior to the study
Acute infection
Persons deprived of their liberty by judicial or administrative decision
Adults subject to legal protection measures (guardianship, curatorship, judicial protection)

Treatment and study plan

RMI and Questionnaires

Other

Magnetic resonance imaging (MRI) will collect anatomical information (3D T1 weighted images) to compute the volumes of the hypothalamus, hippocampus and the other brain parcels.

Executive functions using the CANTAB tests and validated questionnaires will be performed.

Primary outcomes

Memory function characteristic

Time frame: 37 months after inclusion day

The main objective is to characterise memory function in a population of middle-aged individuals suffering from obesity using the CANTAB Paired Associates Learning (PAL) test.

Study contacts

Contact information is provided by the study sponsor or research team.

Blandine GATTA-CHERIFI, Pr

CONTACT

[email protected]

05 24 54 93 41 ext. +33

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Registry information

Acronym: MNEMOB

Important dates

Study start: 2027
Primary completion: 2030
Study completion: 2030
First posted: Sep 1, 2026
Registry last updated: Sep 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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