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NCT Number: NCT07796269

Post-Extraction Wound Healing in Elderly

Patients presenting to the University of Nebraska Medical Center College of Dentistry for a posterior extraction will be offered participation in the study. Prior to extraction, subjects will undergo clinical measurements, xray, gingival crevicular fluid (GCF) and saliva sampling and a blood draw. Following atraumatic tooth extraction, the subjects will be reevaluated for healing at 1, 2-weeks and 3 months. At each appointment, GCF, saliva and wound fluid (WF) will be collected and at 3 months a second xray will be taken.

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Key information

Conditions

Wound Healing

Age range

65 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Nebraska Medical Center College of Dentistry

Lincoln, Nebraska, 68583, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • needs posterior tooth extracted
  • no systemic conditions or meds affecting wound healing
  • non-smoker

Exclusion criteria

  • systemic conditions or meds known to affect wound healing
  • smokers

Treatment and study plan

Tooth extraction

Procedure

posterior tooth extraction

Primary outcomes

  1. Amount of Interleukin-1 beta (IL1-B) in gingival crevicular at baseline

    Time frame: Baseline

    Measurement of IL1B in GCF

Secondary outcomes

  1. Bone Density

    Time frame: 3 months

    Change in bone density post-extraction

Interested in participating?

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Sponsors and collaborators

Lead sponsor

University of Nebraska

Other

Registry information

Important dates

Study start
2026
Primary completion
2028
Study completion
2030
First posted
Sep 1, 2026
Registry last updated
Sep 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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