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Completed

NCT Number: NCT07795710

Intermittent Bolus Doses of Phenylephrine, Norepinephrine and Ephedrine for the Management of Spinal Induced Hypotension in Preeclamptic Patients

intermittent bolus doses of phenylephrine, norepinephrine and ephedrine for the management of spinal induced hypotension in preeclamptic patients

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Key information

Conditions

Ephedrine Norepinephrine

Age range

20 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Minia University

Minya, Egypt

About this study

A Comparative study of intermittent bolus doses of phenylephrine, norepinephrine and ephedrine for the management of spinal induced hypotension in preeclamptic patients

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Preeclamptic pregnant female
  • ASA II and III
  • singleton or twin pregnancies will be scheduled for caesarean delivery
  • diagnosis of preeclampsia as a new onset of hypertension and proteinuria.

Exclusion criteria

  • chronic hypertension, labor or failed trial of labor,
  • body mass index ≥40 kg/m2 ,
  • resting heart rate <60 bpm, eclampsia,
  • known fetal anomalies, contraindications to spinal anesthesia, abruption placentae, and cord prolapas.

Treatment and study plan

Group 1 (P)

Drug

receive bolus dose of phenyelepherine 75 ug

Group 2( N)

Drug

Group 2( N) will receive bolus dose of noradrenaline 4 ug

Group 3( E)

Drug

Group 3( E) will receive bolus dose ephedrine 4 mg

Primary outcomes

  1. Heart rate changes

    Time frame: every 3 minutes till 40 minutes

Secondary outcomes

  1. Systolic blood pressure

    Time frame: every 3 minutes till 40 minutes

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Official study title

A Comparative Study of Intermittent Bolus Doses of Phenylephrine, Norepinephrine and Ephedrine for the Management of Spinal Induced Hypotension in Preeclamptic Patients

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Aug 31, 2026
Registry last updated
Aug 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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