Comparison of KIRA Hydrating Treatment and Jet Peel for Facial Skin Hydration

This study compared the efficacy and tolerability of two non-invasive facial treatment systems for improving skin hydration: a hydroabrasion-jet system (KIRA) and a conventional high-pressure jet system (JET PEEL). Twenty-three women aged 30-65 years underwent three treatment sessions using an intraindividual split-face design, with KIRA applied to the left side of the face and JET PEEL to the right side. Skin hydration was assessed by corneometry at baseline, 48 hours after the first treatment, and before the second and third treatments, with the measurement before the third treatment defined as the primary endpoint. Additional exploratory assessments included multispectral skin imaging, participant-reported treatment experience and preference, and a Day-21 follow-up. The study aimed to determine whether enhanced epidermal preparation using hydroabrasion combined with lower-pressure jet infusion could achieve hydration outcomes comparable to those obtained with a conventional higher-pressure jet system.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Facial Skin Hydration Skin Rejuvenation

Age range

30 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Laser Center Be You, Be You Technology d.o.o., Belgrade, Serbia

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Female participants aged 30-65 years Fitzpatrick skin types II-III Presence of signs of facial skin aging, including one or more of the following: hyperkeratosis, hyperpigmentation, facial or age-related wrinkles, and enlarged pores Generally healthy and without contraindications to the study procedures Willing and able to provide informed consent and participate in the study procedures

Exclusion criteria

Pregnancy or breastfeeding Serious vascular disorders Pacemaker or metal implants in the treatment area Malignant skin disease Autoimmune or endocrine disease, diabetes, or AIDS Psoriasis, herpes, or other active skin disease Infection in the treatment area Tendency toward keloid scarring or allergic reactions Long-term corticosteroid therapy or other medication considered incompatible with the procedures Hyaluronic acid filler or botulinum toxin injections in the treatment area Tattoo or permanent makeup in the treatment area Invasive aesthetic procedures within the previous 5 months Failure to meet the inclusion criteria

Treatment and study plan

Hydroabrasion and Jet Infusion

Device

Vacuum-assisted hydroabrasion was used for epidermal preparation, followed by jet infusion at 5 bar. The intervention was applied to the left facial side during three treatment sessions.

High-Pressure Jet Infusion

Device

Jet-based treatment and infusion at 6.89 bar was applied to the right facial side during three treatment sessions.

Primary outcomes

Change in Facial Skin Hydration From Baseline to T3

Time frame: Baseline (T0) to before the third treatment session (T3; approximately 14 days)

Facial skin hydration was measured separately on the KIRA-treated and JET PEEL-treated facial sides using corneometry. The primary outcome was the change in corneometer-measured skin hydration, expressed in arbitrary units (a.u.), from baseline (T0) to T3, measured before the third treatment session. The within-participant difference in change between the two facial sides was used for the primary comparison.

Sponsors and collaborators

Lead sponsor

Faculty of Pharmacy Novi Sad

Other

Registry information

Official study title

Split-Face Comparison of Vacuum Hydroabrasion-Jet System Versus Conventional High-Pressure Jet Peel System for Facial Rejuvenation

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Aug 28, 2026
Registry last updated: Aug 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed