The Effect of Connective Tissue Massage on Pressure Pain Threshold in Fibromyalgia

The aim of this randomized controlled study is to investigate the immediate effect of connective tissue massage (CTM) on the pressure pain threshold (PPT) in women with fibromyalgia.

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Key information

Conditions

Fibromyalgia Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases Pressure Pain Threshold Rheumatic Diseases

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Having a diagnosis of FM
Being a woman between the ages of 18 and 65
Being willing to participate in the study

Exclusion criteria

Diagnosed additional neurological, infectious, and other inflammatory rheumatic diseases; uncontrolled endocrine and/or autoimmune diseases
Severe psychiatric disorders
Pregnancy or breastfeeding
Malignancy
Presence of acute inflammation, open wounds, or erythema in the massage areas

Treatment and study plan

Connective Tissue Massage

Other

Single-session CTM application for the entire back

Primary outcomes

Measurement of pressure pain threshold

Time frame: Baseline and 20 minutes post-intervention

PPT will be determined using a handheld digital algometer with a 1 cm² probe. Measurements will be taken bilaterally at three points: the trapezius, lumbar region, and pretibial area. In the control group, the first measurement will be taken, followed by a second measurement approximately 20 minutes later. In the CTM group, measurements will be taken before and after the CTM procedure.

Sponsors and collaborators

Lead sponsor

Ankara Yildirim Beyazıt University

Other

Registry information

Official study title

Investigation of the Immediate Effect of Connective Tissue Massage on Pressure Pain Threshold in Fibromyalgia

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2027
First posted: Aug 27, 2026
Registry last updated: Aug 31, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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