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NCT Number: NCT07791030

Diagnostic and Prognostic Roles of Procalcitonin and Highly Sensitive C-Reactive Protein in Early Detection of Burn Sepsis

This study aimed to evaluate the value of procalcitonin and highly sensitive c-reactive protein as biomarkers for early detection of sepsis in patients with major burns.

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Key information

Conditions

Diagnostic Role Burn Sepsis C-reactive Protein Early Detection Highly Sensitive Hypersensitivity Immune System Diseases Procalcitonin Prognostic Role

Age range

3 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Mansoura University

Al Mansurah, Dakahlia Governorate, 35516, Egypt

About this study

Severe burn injuries can cause a marked inflammatory stress response. As the inflammatory state progresses, pro-inflammatory cytokines are continuously released.

C reactive protein (CRP) is closely related to the systemic inflammation in its acute phase, as CRP binds to the damaged cell membranes that associates burn injuries and contributes to the associated inflammatory response.

Procalcitonin (PCT) a precursor protein for calcitonin, which is synthesized by thyroid C-cells, is yet another biomarker valuable in the sepsis diagnosis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age from 3 years to 65 years.
  • Both sexes.
  • Patients with major burn (2nd and 3rd degrees of burn).

Exclusion criteria

  • Patients with unrealistic expectations.
  • Patients with inhalational burn injury.
  • Patients with uncompensated chronic disease e.g. hepatic, renal.
  • Patients with mental or psychological troubles affecting the study

Treatment and study plan

Measurement of Procalcitonin level

Diagnostic Test

Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.

Measurement of c-reactive protein level

Diagnostic Test

Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.

Primary outcomes

  1. Measurement of c-reactive protein level

    Time frame: 5 days of burn injury

    Two samples was collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.

Secondary outcomes

  1. Measurement of procalcitonin level

    Time frame: 5 days of burn injury

    Two samples were collected from each patient, one on admission or within the 1st 24 hours of burn and the 2nd were after 3 days.

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 27, 2026
Registry last updated
Aug 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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