Multi-Parameter Temporal Interference Stimulation in Patients With Epilepsy Undergoing SEEG Monitoring

Inclusion criteria

• Aged 18 to 70 years, inclusive, with no restriction on sex.
• Has undergone stereoelectroencephalography (SEEG) electrode implantation, with electrode contacts covering the target deep brain region(s), such as the thalamus, hippocampus, amygdala, or cingulate cortex.
• Is in the postoperative SEEG monitoring period, is clinically stable, and is able to comply with the study procedures.
• The participant or the participant's legally authorized representative is able to fully understand the purpose and procedures of the study and voluntarily provides written informed consent.

Exclusion criteria

• Contraindications to magnetic resonance imaging (MRI), such as incompatible metallic implants or a cardiac pacemaker.
• Psychiatric disorders or severe cognitive impairment.
• Structural brain abnormalities, such as cerebral infarction, hydrocephalus, or severe thalamic atrophy.
• Other severe neurological disorders that may interfere with participation in the study.
• Medical or psychiatric contraindications, including recent myocardial infarction, cardiac arrhythmia, stroke, autonomic dysfunction, endocrine disorders, uncontrolled or difficult-to-control hypertension or hypotension, deep brain stimulation for other reasons, degenerative central nervous system disorders, or severe electrolyte disturbances.
• Pregnancy or breastfeeding.
• Participation in another drug or medical device clinical study within 3 months before screening.
• Any other condition that, in the investigator's judgment, makes the participant unsuitable for the study.