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Completed

NCT Number: NCT07789561

Functional Food Product

Background/Objective: This study evaluated the effects of pomegranate peel powder (PPP)-enriched muffins containing 1.5 g or 2.5 g PPP on H. pylori, inflammation, oxidative stress, and gastric ulcer healing in patients with gastric ulcers.

Conclusion: PPP-enriched muffins showed potential as a functional dietary intervention for improving antioxidant and anti-inflammatory status and supporting gastric ulcer healing.

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Key information

Conditions

Ulcer Blood Tests Digestive System Diseases Duodenal Diseases Gastrointestinal Diseases Intestinal Diseases Liver Function Tests Pathologic Processes Pathological Conditions, Signs and Symptoms Peptic Ulcer Stomach Diseases Stomach Ulcer

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sana Noreen

Lahore, Punjab Province, 54000, Pakistan

About this study

Background/Objective: This study investigated the therapeutic potential of pomegranate peel powder (PPP), a polyphenol- and antioxidant-rich ingredient, incorporated into whole-wheat muffins at doses of 1.5 g and 2.5 g for patients with gastric ulcers. The study assessed its potential effects on H. pylori infection, gastric inflammation, oxidative stress, and mucosal healing.

Conclusion: PPP-enriched muffins were evaluated as a functional dietary intervention with potential gastroprotective, antioxidant, and anti-inflammatory properties, supporting their possible role in dietary management of gastric ulcers.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both male and female patients aged 40-60 years with confirmed Helicobacter pylori infection, verified through stool antigen testing along with elevated pepsinogen I and II levels, were included in the study

Exclusion criteria

pregnancy or lactation, history of gastric surgery, and current use of proton pump inhibitors. and use of medication

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Treatment and study plan

pomegranate peel powder 1.5 g

Dietary Supplement

Whole wheat muffin enriched with pomegranate peel powder (PPP=1.5 g) + conventional Therapy

pomegranate peel powder 3 g

Dietary Supplement

Whole wheat muffin enriched with pomegranate peel powder (PPP=3g) + conventional Therapy

WHOLE WHEAT MUFFIN

Dietary Supplement

Whole wheat muffin

Primary outcomes

  1. Liver Enzymes

    Time frame: 9 weeks

Secondary outcomes

  1. H.phylori

    Time frame: 9 weeks

Sponsors and collaborators

Lead sponsor

University of Lahore

Other

Registry information

Official study title

Gastroprotective Effects of Pomegranate (Punica Granatum L.) Peel Powder-Enriched Functional Food in Gastric Ulcer Management

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Aug 27, 2026
Registry last updated
Aug 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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