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NCT Number: NCT07787741

CERVICAL EPIDURAL BLOCK IN CHRONIC NECK PAIN

Chronic neck pain can negatively affect daily activities, work ability, and quality of life. Cervical epidural block is commonly used to reduce pain and inflammation, while exercise and physical therapy aim to improve muscle strength, endurance, movement control, and physical function. However, there is limited evidence comparing cervical epidural block alone with its combined use with exercise or physical therapy.

This study aims to compare the effects of three treatment approaches in patients with chronic neck pain associated with cervical disc pathology or degenerative changes. Participants will receive cervical epidural block alone, cervical epidural block combined with cervical stabilization exercises, or cervical epidural block combined with physical therapy. Pain intensity, neck-related disability, and quality of life will be evaluated before treatment and at 1, 3, and 6 months after treatment using the Numeric Rating Scale, Neck Disability Index, and 12-Item Short Form Health Survey. The study will determine whether adding exercise or physical therapy to cervical epidural block provides additional clinical and functional benefits.

Recruiting

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Key information

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sakarya Training and Research Hospital

Adapazarı, Sakarya, 54100, Turkey (Türkiye)

Location status: Recruiting

Location contact

YUNUS TÜRKYILMAZ, MD

CONTACT

[email protected]

+905415096040

About this study

Chronic neck pain is a common musculoskeletal condition associated with limitations in daily activities, reduced work capacity, and impaired quality of life. Cervical disc degeneration and herniation are among the structural conditions that may contribute to persistent neck pain. Although education, medications, exercise, and physical therapy are commonly used as conservative treatments, symptoms may persist in some patients. Cervical epidural block is used in clinical practice to reduce pain and inflammation associated with cervical disc pathology.

Exercise and physical therapy may complement the effects of cervical epidural block by improving cervical muscle strength, endurance, neuromuscular control, and physical function. However, evidence directly comparing cervical epidural block alone with its combined use with cervical stabilization exercises or physical therapy is limited. This three-group study will compare the clinical and functional effects of these treatment approaches in patients with chronic neck pain associated with cervical disc pathology or degenerative changes. The findings may help determine whether adding exercise or physical therapy to cervical epidural block provides additional benefits and may guide treatment planning for patients with chronic neck pain.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 to 55 years
  • Neck pain lasting longer than 3 months
  • Diagnosis of cervical radiculopathy
  • Numeric Rating Scale (NRS) pain score of 5 or higher

Exclusion criteria

  • History of spinal surgery
  • Cervical spondylolisthesis
  • Spinal stenosis
  • Presence of a neurological deficit
  • History of psychiatric disease
  • Polyneuropathy
  • History of spinal fracture
  • Pregnancy
  • History of malignancy
  • Known allergy to any medication used in the study
  • Central sensitization
  • Widespread pain
  • Regional pain associated with a systemic disease

Treatment and study plan

Cervical epidural steroid injection

Procedure

Participants receive a cervical epidural steroid injection for the treatment of chronic neck pain associated with cervical radiculopathy.

Cervical Stabilization Exercise Program

Behavioral

Participants perform a cervical stabilization exercise program in addition to cervical epidural steroid injection.

physical therapy program

Other

Participants receive a physical therapy program in addition to cervical epidural steroid injection.

Primary outcomes

  1. Change in Pain Intensity Assessed by the Numeric Rating Scale

    Time frame: Baseline and 1, 3, and 6 months after treatment

    Pain intensity will be assessed using the Numeric Rating Scale (NRS). Participants rate their pain on an 11-point scale ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Lower scores indicate lower pain intensity. Changes from baseline will be compared among the three treatment groups.

Secondary outcomes

  1. Change in Neck-Related Disability Assessed by the Neck Disability Index

    Time frame: Baseline and 1, 3, and 6 months after treatment

    Neck-related disability will be assessed using the Neck Disability Index (NDI). The questionnaire consists of 10 items, each scored from 0 to 5, with a total score ranging from 0 to 50. Higher scores indicate greater neck-related disability. Changes from baseline will be compared among the three treatment groups.

  2. Change in Health-Related Quality of Life Assessed by the 12-Item Short Form Health Survey

    Time frame: Baseline and 1, 3, and 6 months after treatment

    Health-related quality of life will be assessed using the 12-Item Short Form Health Survey (SF-12). The questionnaire provides Physical Component Summary and Mental Component Summary scores. Higher scores indicate better health-related quality of life. Changes from baseline will be compared among the three treatment groups.

Study contacts

Contact information is provided by the study sponsor or research team.

YUNUS TÜRKYILMAZ, MD

CONTACT

[email protected]

+905415096040

Sponsors and collaborators

Lead sponsor

Alİ Eman, MD

Other

Registry information

Official study title

COMPARISON OF CERVICAL EPIDURAL BLOCK ALONE VERSUS COMBINED TREATMENT MODALITIES IN CHRONIC NECK PAIN

Acronym: CNP-TREAT

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 26, 2026
Registry last updated
Aug 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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