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OpenTrials
Not yet recruiting

NCT Number: NCT07786467

Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations

The investigators are studying if a specific osteopathic manipulative treatment protocol can improve the immune response (antibody titers) to seasonal influenza vaccination in vulnerable populations, including patients with advanced age and/or adiposity.

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Trial opening soon.

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Key information

Conditions

No Disease or Condition is Being Directly Studied Infections Influenza, Human Orthomyxoviridae Infections RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections The Focus of the Study in Healthy Volunteers Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Plaza 38 Medical Offices

Erie, Pennsylvania, 16509, United States

Location contact

Amanda Parker, BS

SUB_INVESTIGATOR

David Duriancik, Ph.D.

PRINCIPAL_INVESTIGATOR

Jacob Cukierski, DO

CONTACT

[email protected]

814-860-8414

Jacob Cukierski, DO

SUB_INVESTIGATOR

Jan Hendryx, DO

SUB_INVESTIGATOR

Jonathan Sharp, BS

SUB_INVESTIGATOR

Kayleigh Skolnick, BS

SUB_INVESTIGATOR

Stephany Esper, DO

CONTACT

[email protected]

814-860-8463

Stephany Esper, DO

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Willing to receive OMT
  • Willing to receive influenza vaccine
  • Older than 18 years of age

Exclusion criteria

  • Younger than 18 years of age
  • Pregnancy or lactation
  • Unwilling to receive the influenza vaccine
  • Unwilling to receive OMT
  • Open wounds
  • Bone fractures
  • Moderate to severe osteoporosis
  • Severe COPD
  • Current/active infections
  • Mononucleosis infection within past 6 months
  • Liver cirrhosis
  • Cancer or metastatic disease
  • History of DVT, PE, or blood clotting disorder
  • Individuals taking blood thinning medications, except aspirin
  • Having a pacemaker or other thoracic medical devices

Treatment and study plan

Osteopathic manipulation

Other

In this intervention, participants will receive 5 minutes of thoracic inlet myofascial release 2 days prior to influenza vaccination, the day of influenza vaccination and 4 days post-influenza vaccination.

SHAM

Other

In this intervention, participants will receive no osteopathic treatments

Primary outcomes

  1. Hemagglutinin inhibition assay

    Time frame: baseline and 4 weeks post vaccination

    Hemagglutinin inhibition assay assess the antibody titers in patient's blood.

Study contacts

Contact information is provided by the study sponsor or research team.

David Duriancik, Ph.D.

CONTACT

[email protected]

814-860-5139

Irv Freeman, J.D., Ph.D.

CONTACT

[email protected]

724-552-2870

Sponsors and collaborators

Lead sponsor

Lake Erie College of Osteopathic Medicine

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 26, 2026
Registry last updated
Aug 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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