Spinal Alignment as a Predictor of Functional Performance in Individuals With Upper Cross Syndrome: A Secondary Analysis of a Randomized Controlled Trial

This study aims to explore the relationship between spinal alignment and functional performance in individuals with upper cross syndrome following a combined breathing and manual therapy program. It is designed as a secondary analysis of data obtained from a previously conducted randomized controlled trial, with the addition of objective spinal measurements using the Spinal Mouse device. Functional performance will be assessed using standardized tests such as the 6-minute walk test and the timed up and go test. Statistical analysis will include correlation and regression models to determine whether spinal alignment parameters can predict functional outcomes. The findings are expected to provide insight into the biomechanical role of posture in functional recovery among individuals with upper cross syndrome.

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Key information

Conditions

Upper Cross Syndrome Functional Performance Oculocerebral hypopigmentation syndrome type Preus Spinal Alignment

Age range

20 year–29 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Full time college students of age 20-29 years.

Subjects who have upper cross syndrome according to REEDCO posture assessment.
Subjects who not receiving medical treatment for respiratory diseases .
Subjects who have clean family medical history.

Exclusion criteria

Subjects who engaged in additional exercise in two weeks, which was likely to affect the results of the research .
Individuals with a history of spine, shoulder fractures, surgery, or other disease.
Individuals with severe cardia-cerebrovascular disease.
Individuals who will have difficulty to follow-up testing).
Neurologic and psychiatric disorders (who can not understand the research project ).
Individuals with congenital deformities

Treatment and study plan

The experimental group will perform ujjayi pranayama and osteopathic manipulative tratment

Other

The experimental group will perform ujjayi pranayama and osteopathic manipulative treatment for 45 min sessions, 5 times a week for 8 weeks

control group will perform osteopathic manipulative treatment only

Other

control group will perform osteopathic manipulative treatment only for 45 min sessions, 5 times a week for 8 weeks

Primary outcomes

Spinal Alignment: Thoracic kyphosis

Time frame: Pre and post 8 weeks

Kyphosis is the forward curvature of the thoracic spine.It will be measured by The Spinal Mouse ( a hand-held, computer-assisted medical device used to measure spinal curvature, posture, and segmental mobility without radiation )
Spinal Alignment: Lumbar lordosis

Time frame: Pre and post 8 weeks

inward curvature of the spine when this curve becomes excessive or diminished, it can lead to discomfort and postural issues.It will be measured by The Spinal Mouse ( a hand-held, computer-assisted medical device used to measure spinal curvature, posture, and segmental mobility without radiation )

Secondary outcomes

Functional Performance: 6-Minute Walk Test (6MWT)

Time frame: Pre and post 8 weeks

a clinical exercise test that measures the total distance an individual can walk on a flat, hard surface over a period of 6 minutes
Functional Performance: Timed Up and Go Test (TUG)

Time frame: Pre and post 8 weeks

measures functional mobility and fall risk. It records the seconds it takes a person to stand up from a standard armchair, walk 3 meters (10 feet), turn around, walk back, and sit down again

Sponsors and collaborators

Lead sponsor

Al-Zaytoonah University of Jordan

Other

Registry information

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Aug 26, 2026
Registry last updated: Aug 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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