Not yet recruiting

NCT Number: NCT07786207

Knee Cartilage Repair Registry

This registry is designed to collect information on how different surgical procedures are used and how well they work in treating knee cartilage damage. Information will be collected from patients undergoing knee surgery for cartilage damage and entered into a large database that reflects routine clinical practice ("real-world" data). The data collected will be used to support future research and improve understanding of treatment outcomes for knee cartilage repair.

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Trial opening soon.

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Key information

Conditions

Knee Injuries Joint Surface Knee Lesions Leg Injuries Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CAO Research Foundation, Washington D.C., District of Columbia, United States

About this study

The registry will collect both prospective and retrospective/prospective data.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Prospective Subjects

Provides written informed consent.
Is eighteen (18) years of age or older at time of consent and considered skeletally mature in the opinion of the investigator.
Scheduled to undergo knee cartilage surgery with the Marketed Product-MP01 OR other knee cartilage repair surgery.
For subjects having other knee cartilage repair surgery:

Falls within Marketed Product-MP01 on label indication: Knee chondral or osteochondral lesions (ICRS grade III and above, 1-7cm2) in patients with or without mild-moderate knee osteoarthritis (K/L 0-3).
Has an electronic device and is willing and able to use the device to complete the 'Electronic Clinical Outcomes Assessment' (eCOA).
Willing and able to complete all requested questionnaires.
Able to follow instructions and deemed capable of completing registry protocol requirements.

Retrospective/Prospective Subjects

Provides written informed consent.
Was eighteen (18) years of age or older at time of surgery and considered skeletally mature at that time in the opinion of the investigator.
Underwent knee cartilage repair surgery with the Marketed Product-MP01 within the last 2-years.
Has an electronic device and is willing and able to use the device to complete the eCOA.
Willing and able to complete all requested questionnaires.
Able to follow instructions and deemed capable of completing registry protocol requirements.
Consents to retrospective data being collected from pre-operative visit(s) and surgery through to the point of consent as available in their medical notes.

Exclusion criteria

History of allergic reaction or intolerance of materials containing calcium carbonate or hyaluronate/coral derivatives.
Is actively participating in a cartilage repair clinical trial.
For subjects having other knee cartilage repair surgery:

Treatment will be on patellar lesion(s).
Has participated previously in this registry (with the index or contralateral knee).
Meets the definition of a Vulnerable Subject per ISO 14155 Section 3.56.

Treatment and study plan

Marketed Product - MP01

Device

Marketed Product - MP01 is a medical device used in the treatment of knee-joint surface lesions.

Other Surgical Treatments

Procedure

Any other surgical procedures used in the treatment of knee-joint surface lesions that fall within the Marketed Product - MP01 on label indication.

Primary outcomes

International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Score change from Baseline to 24-months

Time frame: Baseline and 24 months

The IKDC Subjective Knee Evaluation Form assesses the subject's opinion of their knee across 3 domains: symptoms (7 items), sports activity (2 items), and knee function (2 items; note: 'function prior to knee injury' is not included in the overall score). Responses vary for each item. The sum of all items is converted to a scale of 0 to 100, where 100 represents no limitation with activities & absence of symptoms (i.e., the best outcome) and 0 represents the worst outcome.

Study contacts

Contact information is provided by the study sponsor or research team.

Judith Horner

CONTACT

[email protected]

+44 (0)1482 673251

Laura Everson

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Smith & Nephew, Inc.

Industry

Registry information

Official study title

Cartilage Repair Study of Health Outcomes and Real-world Evidence (C-SHORE)

Acronym: C-SHORE

Important dates

Study start: 2026
Primary completion: 2034
Study completion: 2034
First posted: Aug 25, 2026
Registry last updated: Aug 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Enrolling by invitation