Skip to main content
OpenTrials
Not yet recruiting

NCT Number: NCT07783737

China Glomerulonephritis Kidney Transplant Recipient Cohort: A Prospective Multicenter Observational Study

This is a prospective observational study aimed at establishing a prospective observational cohort of patients with a confirmed diagnosis of glomerulonephritis (GN) before kidney transplantation in China. Information will be collected on the epidemiology of GN recurrence after kidney transplantation, as well as the outcomes and treatment of the primary disease following kidney transplantation, to provide evidence for subsequent clinical studies, drug development, and translational research.

Approximately 300 patients with a confirmed diagnosis of GN before transplantation will be prospectively enrolled. Clinical data will be collected during screening, kidney transplantation, and a 3-year post-transplant follow-up. The frequency of follow-up visits is every 3 months in the 1st year after transplantation, and every 6 months during the 2nd to 3rd years, with a total of 8 follow-up visits. The study will be conducted at 10 sites across China.

Not yet recruiting

Trial opening soon.

Get Notified

Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years.
  • Diagnosed with primary GN based on clinical guidelines and/or expert consensus
  • Successfully matching completed and confirmed to be scheduled for kidney transplantation.

Exclusion criteria

  • History of organ transplantation or planned multiple organ transplantation.
  • Complicated with malignancy.
  • Failure to undergo kidney transplantation for any reason.
  • Unable to provide written informed consent form (ICF).

Treatment and study plan

Primary outcomes

  1. To assess the incidence of GN recurrence after kidney transplantation and its influencing factors

    Time frame: 3-year follow-up

    Incidence of GN recurrence after kidney transplantation

  2. To assess the incidence of GN recurrence after kidney transplantation and its influencing factors

    Time frame: 3-year follow-up

    Time to GN recurrence after kidney transplantation (months)

  3. To assess the incidence of GN recurrence after kidney transplantation and its influencing factors

    Time frame: 3-year follow-up

    Factors associated with GN recurrence after kidney transplantation

Secondary outcomes

  1. To assess other clinical events after kidney transplantation and their associated factors

    Time frame: 3-year follow-up

    incidence and time to rejection

  2. To assess other clinical events after kidney transplantation and their associated factors

    Time frame: 3-year follow-up

    incidence and time to renal allograft loss

  3. To assess other clinical events after kidney transplantation and their associated factors

    Time frame: 3-year follow-up

    incidence and time to death

Interested in participating?

Not yet recruiting

Trial opening soon.

Get Notified

Sponsors and collaborators

Lead sponsor

AstraZeneca

Industry

Registry information

Important dates

Study start
2026
Primary completion
2030
Study completion
2030
First posted
Aug 25, 2026
Registry last updated
Aug 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.