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NCT Number: NCT07783399

The Effects of Carnitine Supplementation on Oocytes in Women Undergoing IVF Process

The goal of this clinical trial is to learn whether supplementation with L-carnitine improves outcomes in women undergoing in vitro fertilization (IVF). It will also evaluate the effect of supplementation on oocyte quality, embryo quality, and pregnancy rates. The main questions it aims to answer are:

* Does supplementation improve the number and quality of oocytes retrieved during IVF treatment? * Does supplementation improve the number and quality of embryos obtained after fertilization? * Does supplementation increase the rates of biochemical and clinical pregnancy?

Researchers will compare women receiving supplementation with women not receiving supplementation to determine whether the supplements improve IVF outcomes.

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Key information

Conditions

Infertility (IVF Patients) Genital Diseases Infertility Urogenital Diseases

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Clinic for Gynecology and Obstetrics Narodni Front

Belgrade, Savski Venac, 11000, Serbia

Location status: Recruiting

Location contact

Vladimir M Gerginic, MD

CONTACT

[email protected]

+381648754284

About this study

Participants will:

  • Be women undergoing IVF treatment at the Narodni Front Clinic of Gynecology and Obstetrics who meet the study eligibility criteria and agree to participate.
  • Be randomly assigned, using the sealed-envelope method, to one of two groups:
  • A supplementation group receiving L-arginine (500 mg), L-carnitine (500 mg), N-acetyl-L-carnitine (250 mg), and myo-inositol (1000 mg) daily.
  • A control group receiving no supplementation.
  • Take the assigned supplementation for 12 weeks before oocyte retrieval.
  • Undergo assessment of the number and quality of retrieved oocytes after oocyte aspiration as part of the standard IVF procedure.
  • If fertilization occurs and embryos are obtained, have the number and quality of embryos evaluated as part of the standard IVF procedure.
  • Have serum beta-human chorionic gonadotropin (β-hCG) measured 13 days after embryo transfer to assess biochemical pregnancy as part of the standard IVF procedure.
  • If biochemical pregnancy is achieved (β-hCG > 50 IU/L), undergo an ultrasound examination 35 days after embryo transfer to confirm clinical pregnancy as part of the standard IVF procedure.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women undergoing IVF process
  • women aged 18-45 years

Exclusion criteria

  • obesity
  • severe kidney disease
  • liver insufficiency
  • endocrine disorders
  • the use of immunosuppressive medications

Treatment and study plan

L-Carnitine Group

Dietary Supplement

A supplementation group will receive L-carnitine (500 mg) daily for 12 weeks before oocyte retrieval.

Primary outcomes

  1. The impact of carnitine supplementation on the number of oocytes retrieved during in vitro fertilization and on IVF outcomes.

    Time frame: 3 months

    Assessment of the total count of oocytes retrieved per patient during transvaginal ultrasound-guided oocyte retrieval following controlled ovarian stimulation.

    Unit of measure: number of oocytes /count/ Measurement tool: inverted light microscope

  2. The impact of carnitine supplementation on the number of good quality oocytes (metaphase II (MII) oocytes) retrieved during oocyte pick-up

    Time frame: 3 months

    Good quality oocytes (metaphase II oocytes) will be identified according to standard ESHRE consensus morphological criteria (evaluating polar body presence, cytoplasm texture, and zona pellucida integrity) using inverted light microscope as measurement tool, following denudation in cases of intracytoplasmatic sperm injection (ICSI) or Metaphase II (MII) oocytes will be identified based on successful fertilization (presence of two pronuclei, 2PN) using inverted light microscope following insemination as part of the IVF procedure.

    Unit of measure: number of metaphase II (MII) oocytes /count/ Measurement tool: inverted light microscope

Study contacts

Contact information is provided by the study sponsor or research team.

Milan D PEROVIC, Ass. Prof., PhD

CONTACT

[email protected]

+381644184953

Sponsors and collaborators

Lead sponsor

The Obstetrics and Gynaecology Clinic Narodni Front

Other

Registry information

Official study title

The Effects of Carnitine Supplementation on Oocyte Yield and Quality in Women Undergoing IVF

Acronym: Carnitine Supp

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 24, 2026
Registry last updated
Aug 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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