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NCT Number: NCT07782398

Momentary Coping Prompts and Hair Steroids in College Students

This study looks at the moments when college students feel a strong emotional swing, and how those moments relate to reacting online when upset, drinking alcohol, and eating in response to emotions. Participants wear a wrist device and answer brief check-ins on their phone several times a day for about five weeks. During part of that time, a study app sometimes sends a short coping message at moments when the wrist device and check-ins suggest emotions are shifting quickly. Whether a message is sent at any given moment is decided at random, and the study compares what participants do in the short window afterward. An optional part of the study collects one small hair sample, which is tested for two hormones related to stress and to status-linked behavior, so the researchers can see whether longer-term hormone levels relate to how people respond in the moment. The study is a pilot designed to test whether the approach works and to estimate how large its effects are.

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Key information

Conditions

Emotional Regulation Aberrant Motor Behavior in Dementia Aggression Alcohol Drinking Alcohol Drinking in College Behavior Behavioral Symptoms Drinking Behavior Emotional Eating Feeding Behavior Self-Control Social Behavior

Age range

18 year–89 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Florida

Gainesville, Florida, 32611, United States

Location contact

Yonghwan Chang, PhD

CONTACT

[email protected]

352-294-1664

Yonghwan Chang, PhD

PRINCIPAL_INVESTIGATOR

About this study

REACT is a five-week micro-randomized trial in University of Florida students age 18 and older. Participants complete a baseline battery, wear a Garmin Venu 3, and respond to five to six smartphone check-ins per day. Week one is a no-prompt run-in that establishes each participant's own baseline distribution of momentary affective variability, indexed by the mean square of successive differences on consecutive affect ratings. From week two through week five, the app evaluates up to six decision points per day. A decision point is flagged when the participant's current variability exceeds their own 80th percentile threshold, computed within person rather than against a group average. At each available decision point the app randomizes with probability 0.5 whether to deliver a brief coping message, and if so selects a message type from those eligible in that context. Availability rules exclude sleep, stale device data, a 60-minute cooldown, a daily cap, and any safety override. Proximal outcomes are drawn from the first check-in within two hours after the decision point. Analysis uses weighted and centered least squares to estimate causal excursion effects, with pre-specified moderators. An optional sub-study collects a single hair sample at the enrollment visit, assayed for cortisol and testosterone, to test whether early-life adversity moderates the association between chronic stress physiology and momentary reactive behavior.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Currently enrolled University of Florida student
  • Age 18 years or older
  • Owns a smartphone used daily
  • Willing to wear a wrist-worn device and complete brief check-ins several times daily for approximately five weeks
  • For the optional hair biomarker sub-study only: at least approximately 1 cm of hair at the posterior vertex, no scalp wound, rash, or dermatologic treatment at the collection site, and natural hair growth accessible at the collection site

Exclusion criteria

  • Varsity student-athlete governed by the university athletic association
  • Unable to complete study procedures in English

Treatment and study plan

Momentary coping prompt

Behavioral

A single short message of one to three sentences delivered to the participant's smartphone at a randomized decision point, taking roughly fifteen to thirty seconds to read. Messages apply cognitive-behavioral techniques including thought records, perspective-taking, decatastrophizing, cost-benefit checks, implementation intentions, and behavioral redirection, or acceptance-based techniques including cognitive defusion, acceptance, values anchoring, urge surfing, and present-moment grounding. Delivery is capped at four messages per day with a minimum sixty-minute interval and is confined to participant-set waking hours. Messages may be dismissed without responding.

Active control message

Behavioral

A brief neutral acknowledgment message matched to the coping messages on delivery mechanism and approximate length, containing no coping technique or behavioral suggestion.

Primary outcomes

  1. Momentary urge to post or reply reactively, score on a 7-point scale.

    Time frame: Within 2 hours after each randomized decision point, across weeks 2 to 5.

    Self-reported urge to post or reply about something upsetting, rated 1 to 7 at the first check-in within two hours after a randomized decision point. Higher scores indicate greater urge. Analyzed as a causal excursion effect comparing decision points at which a coping message was delivered with those at which it was not.

  2. Momentary urge to drink alcohol, score on a 7-point scale.

    Time frame: Within 2 hours after each randomized decision point, across weeks 2 to 5.

    Self-reported current urge to drink alcohol, rated 1 to 7 at the first check-in within two hours after a randomized decision point. Higher scores indicate greater urge. Analyzed as a causal excursion effect.

  3. Momentary emotional influence on eating, score on a 7-point scale.

    Time frame: Within 2 hours after each randomized decision point, across weeks 2 to 5

    Self-reported rating of how much emotions influenced eating since the previous check-in, rated 1 to 7 at the first check-in within two hours after a randomized decision point. Analyzed as a causal excursion effect.

Secondary outcomes

  1. Momentary reactive online behavior since the previous check-in, self-reported occurrence

    Time frame: Within 2 hours after each randomized decision point, across weeks 2 to 5

    Self-reported occurrence of posting or replying while upset since the previous check-in, reported yes or no at the first check-in within two hours after a randomized decision point.

  2. Number of standard drinks consumed since the previous check-in, self-reported count

    Time frame: Within 2 hours after each randomized decision point, across weeks 2 to 5

    Self-reported number of standard drinks consumed since the previous check-in.

  3. Loss-of-control eating rating, score on a 7-point scale.

    Time frame: Within 2 hours after each randomized decision point, across weeks 2 to 5

    Self-reported sense of losing control while eating since the previous check-in, rated 1 to 7.

  4. Proportion of scheduled check-ins completed.

    Time frame: Through study completion, approximately 5 weeks per participant.

    Number of completed check-ins divided by number of scheduled check-ins. Pre-registered feasibility benchmark is 75 percent.

  5. Proportion of delivered prompts receiving a response

    Time frame: Through study completion, approximately 5 weeks per participant.

    Number of prompts receiving a rating response divided by number of prompts delivered. Pre-registered benchmark is 60 percent.

  6. Proportion of waking hours with valid wearable data.

    Time frame: Through study completion, approximately 5 weeks per participant.

    Hours of valid physiological data divided by estimated waking hours. Pre-registered benchmark is 80 percent.

  7. Proportion of enrolled participants retained to study end.

    Time frame: Through study completion, approximately 5 weeks per participant.

    Number of participants completing the study divided by number enrolled. Pre-registered benchmark is 85 percent.

  8. Proportion of sub-study participants providing a usable hair sample.

    Time frame: Enrollment visit

    Number of usable hair samples divided by number of sub-study participants. Pre-registered benchmark is 90 percent.

  9. Prompt helpfulness rating, score on a 7-point scale.

    Time frame: Week 3 and end of study, approximately week 5.

    Participant rating of how helpful the coping prompts were, rated 1 to 7.

  10. System Usability Scale total score

    Time frame: End of study, approximately week 5.

    System Usability Scale (Brooke, 1996) total score, range 0 to 100, higher scores indicating better usability.

Other outcomes

  1. Exploratory: concentration of hair cortisol, pg/mg.

    Time frame: Enrollment visit, single hair sample reflecting approximately the prior 3 months.

    Hair cortisol concentration in picograms per milligram assayed from a single hair sample. This measure is exploratory.

  2. Exploratory: concentration of hair testosterone, pg/mg.

    Time frame: Enrollment visit, single hair sample reflecting approximately the prior 3 months.

    Hair testosterone concentration in picograms per milligram assayed from a single hair sample. This measure is exploratory.

  3. Exploratory: correlation between hair cortisol concentration and momentary reactive behavior score, stratified by adverse childhood experiences score.

    Time frame: Baseline hair sample, with momentary outcomes across weeks 2 to 5.

    Correlation between hair cortisol concentration (pg/mg) and momentary reactive behavior score (7-point scale), examined separately by adverse childhood experiences score measured with the ACE questionnaire (range 0 to 10). This measure is exploratory.

  4. Exploratory: correlation between hair testosterone concentration and momentary reactive behavior score.

    Time frame: Baseline hair sample, with momentary outcomes across weeks 2 to 5

    Correlation between hair testosterone concentration (pg/mg) and momentary reactive behavior score (7-point scale). This measure is exploratory.

Study contacts

Contact information is provided by the study sponsor or research team.

Yonghwan Chang, PhD

CONTACT

[email protected]

352-294-1664

Sponsors and collaborators

Lead sponsor

University of Florida

Other

Registry information

Official study title

REACT Biomarker and Extended-Measures Study: Hair Steroids, Psychosocial Moderators, and Momentary Reactive Behavior in College Students

Acronym: REACT-Bio

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 24, 2026
Registry last updated
Aug 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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