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Enrolling by invitation

NCT Number: NCT07781592

Exercise Intensity and Heat Responses in Children and Youth

Little is known about how children and youth regulate body temperature during exercise in the heat compared with young adults, including whether differences in whole-body heat exchange contribute to their responses. The goal of this clinical trial is to determine how exercise intensity affects thermoregulation in boys and girls aged 9-16 years compared with young adult men and women aged 20-25 years. Participants will complete three study visits in a hot environment of 36°C (degree Celcius (97°F, degree Farenheit)), performing light-, moderate-, and vigorous-intensity exercise corresponding to metabolic heat production of 120, 160, and 200 W/m² (w=watts, m=meter), respectively. During each visit, participants will complete four 15-minute bouts of exercise (i.e., bout 1, 2, 3 and 4 respectively) separated by 15-minute rest periods. Testing will be performed in a whole-body air calorimeter, a specialized chamber that precisely measures heat lost through evaporation and dry heat exchange and the amount of heat stored in the body. These measurements, together with core temperature and heart rate, will allow researchers to determine how increasing exercise intensity affects the body's ability to lose heat and whether these responses differ between children and youth and young adults.

Enrolling by invitation

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Key information

Age range

9 year–25 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

University of Ottawa

Ottawa, Ontario, K1N 6N5, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male or female.
  • Aged 9-16 years or 20-25 years.
  • Habitually active, defined as participating in regular physical activity at least 3 times per week for at least 20 minutes per session over the previous 6 months.
  • Able to understand and communicate in English or French.
  • For participants younger than 18 years, written parental or guardian consent and participant assent are required.

Exclusion criteria

  • Acute illness at the time of testing (e.g., cold, flu, or infection).
  • History of a chronic medical condition that may affect thermoregulation, cardiovascular function, or exercise capacity (e.g., cardiovascular disease, metabolic disorders, respiratory disease including asthma requiring regular medication, or neurological disorders).
  • Use of medications known to affect thermoregulation, hydration status, or cardiovascular responses.
  • History of heat-related illness (e.g., heat exhaustion or heat stroke).
  • Digestive abnormalities or gastrointestinal conditions that may contraindicate ingestion of a telemetry pill.
  • Any condition that, in the opinion of the investigators, would compromise participant safety or the integrity of the data.

Treatment and study plan

Low-Intensity Exercise in the Heat

Other

Participants complete intermittent low-intensity exercise at a metabolic heat production of 120 W/m² (w=watts; m=meter) in a hot environment of 36°C (degree Celsius (97°F, degree Fahrenheit)).

Moderate-Intensity Exercise in the Heat

Other

Participants complete intermittent moderate-intensity exercise at a metabolic heat production of 160 W/m² in a hot environment of 36°C (97°F).

Vigorous-Intensity Exercise in the Heat

Other

Participants complete intermittent vigorous-intensity exercise at a metabolic heat production of 200 W/m² in a hot environment of 36°C (97°F).

Primary outcomes

  1. Core temperature

    Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)

    Core temperature indexed by visceral (telemetry pill) temperature

Secondary outcomes

  1. Evaporative heat loss

    Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)

    Evaporative heat loss as assessed using a direct air calorimeter.

  2. Dry heat loss

    Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)

    Dry heat loss as assessed using a direct air calorimeter.

  3. Whole-body total heat loss

    Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)

    Total heat loss (dry + evaporative) as assessed using a direct air calorimeter

  4. Body Heat Storage

    Time frame: Change from start to the end for each of the four 15 minutes exercise bouts

    Heat stored in the body for each of the exercise bouts

  5. Skin Temperature

    Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)

    Skin temperature measured at 8-sites (forehead, chest, scapula, upper arm, forearm, hand, thigh, calf) with mean value calculated as weighted value of 8 sites - forehead, 7%; chest, 17.5%; scapula, 17.5%, upper arm, 7%; forearm, 7%; hand, 5%; thigh, 19%; and calf, 20%.

  6. Change in skin temperature

    Time frame: Change from start to the end for each of the four 15 minutes exercise bouts

    Skin temperature measured at 8-sites (forehead, chest, scapula, upper arm, forearm, hand, thigh, calf) with mean value calculated as weighted value of 8 sites - forehead, 7%; chest, 17.5%; scapula, 17.5%, upper arm, 7%; forearm, 7%; hand, 5%; thigh, 19%; and calf, 20%.

  7. Heart rate

    Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)

    Measured continuously with chest-band device

  8. Thermal Sensation Scale

    Time frame: End of each of the four 15 minutes exercise bouts (average of last 5 minutes)

    Thermal sensation will be assessed using the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE) 7-point scale ("0=neutral to 7=extremely hot")

Sponsors and collaborators

Lead sponsor

University of Ottawa

Other

Registry information

Official study title

Effects of Exercise Intensity on Thermoregulation in the Heat in Children and Youth

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Aug 24, 2026
Registry last updated
Aug 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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