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NCT Number: NCT07779200

Bicarbonate HD Study

The primary goal of this single centre observational study is to look at factors that affect serum bicarbonate levels in patients on maintenance dialysis. This will be done by collecting demographic information, relevant medical history, dialysis history, potential renal acid load from diet by recording different foods consumed over 2 days in a food diary and bicarbonate levels at 3 intervals, pre and post dialysis session 1 and pre dialysis session 2.

Bicarbonate levels are of significant interest as an indicator of metabolic acidosis in CKD dialysis patients. This study will allow us to understand the efficacy of different dialysis modalities in controlling bicarbonate levels. It will also enable us to understand the idea of individualizing dialysis for patients in terms of not using a standard concentration of dialysate for all patient undergoing dialysis in this center.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

East and North Hertfordshire NHS Trust

Stevenage, Hertfordshire, SG1 4AB, United Kingdom

Location status: Recruiting

Location contact

Enric Vilar

CONTACT

[email protected]

01438 284230 ext. 4230

Simran Sorathia

CONTACT

[email protected]

01438 284230 ext. 4230

Simran Sorathia

PRINCIPAL_INVESTIGATOR

About this study

Cross sectional study

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years and above.
  • Ability to give informed consent.
  • End Stage Renal Disease established on maintenance dialysis for at least 3 months.
  • Patients on dialysis 3 times a week

Exclusion criteria

  • Inability to give informed consent
  • Patients with acute kidney injury
  • Patients with severe COPD

Treatment and study plan

Primary outcomes

  1. Change in serum bicarbonate levels in patients on haemodialysis

    Time frame: 3 months

    Serum bicarbonate concentration measured across two dialysis sessions (HD1 and HD2) measured as Pre HD1, Post HD2 and Pre HD2.

Secondary outcomes

  1. Dietary Acid Load

    Time frame: ~ 3 months

    Potential renal acid load

  2. Volume of Haemodiafiltration

    Time frame: 3 months

    Haemodiafiltration volume delivered

  3. Indicators of dialysis dose

    Time frame: 3 months

    Pre HD1 and Post HD1 serum urea

Study contacts

Contact information is provided by the study sponsor or research team.

Enric Vilar

CONTACT

[email protected]

01438 284230 ext. 4230

Simran Sorathia

CONTACT

[email protected]

01438 284230 ext. 4230

Sponsors and collaborators

Lead sponsor

East and North Hertfordshire NHS Trust

Other Gov

Registry information

Official study title

Factors Affecting Bicarbonate Levels In Patients On Haemodialysis

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 21, 2026
Registry last updated
Aug 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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