BL1107 Response and Intensity Guided Dosing for Hyperemia Resolution Trial

Trial RX01-BL1107-1202 is designed to identify the lowest effective concentration of BL1107 required for complete resolution of conjunctival hyperemia in participants with DED. Participants will be masked to concentration of BL1107 received.

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Key information

Conditions

Dry Eye Disease Dry Eye Syndromes Eye Diseases Lacrimal Apparatus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Documented diagnosis of dry eye disease
Conjunctival hyperemia in both eyes, without clinical signs of infection or allergic conjunctivitis

Exclusion criteria

Any active ocular disease
Anticipated wearing of contact lenses during study

Additional criteria per protocol

Treatment and study plan

BL1107

Drug

BL1107 topical ocular solution

Primary outcomes

Primary Part 1: Proportion of participants with complete resolution in conjunctival hyperemia at 30 minutes, in each evaluated concentration of BL1107.

Time frame: Assessed at 30 minutes
Primary Part 2: Proportion of participants with complete resolution in conjunctival hyperemia at 8 hours, in each evaluated concentration of BL1107

Time frame: Assessed at 8 hours

Study contacts

Contact information is provided by the study sponsor or research team.

Johnson Varughese

CONTACT

[email protected]

9089271162

Sponsors and collaborators

Lead sponsor

Bausch & Lomb Incorporated

Industry

Registry information

Official study title

Phase 2a Masked Trial to Identify the Lowest Effective Concentration of BL1107 for Conjunctival Hyperemia in Patients With Dry Eye Disease

Acronym: BRIGHT

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Aug 21, 2026
Registry last updated: Aug 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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