Immunohistochemical Expression of Cyclin D1 in Oral Squamous Cell Carcinoma: Relationship With Clinicodemographic and Histopathological Features

Oral squamous cell carcinoma is a major public health problem , especially in West Asian countries. Cyclin D1 accelerates cell cycle and thus may be implicated in uncontrolled cellular proliferation and tumor progression.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Oral Squamous Cell Carcinoma (OSCC) Carcinoma Carcinoma, Squamous Cell Head and Neck Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Squamous Cell Carcinoma of Head and Neck

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag, Egypt

About this study

Oral squamous cell carcinoma is a major public health problem in different parts of the world. Despite marvelous improvement in treatment modalities -surgical approaches, chemotherapy and radiotherapy- the overall survival ad disease-free survival remain unchanged. so, there a need for studying tumor biology and micro environment. Cyclin D1 is a protein which enhances cell cycle through binding with cyclin-dependent kinases. Over expression of Cyclin D1 may by responsible for the aggressive behavior of oral squamous cell carcinoma through uncontrolled cellular proliferation. in current study, we have detected Cyclin D1 expression in 34 cases of oral squamous cell carcinoma. We detected relationship between intensity of expression and certain parameters as tumor grade, lymphovascular and perineural invasion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with oral squamous cell carcinoma.

Exclusion criteria

patients with oral carcinoma other than squamous cell carcinoma.
patients who received pre-operative radiotherapy.
patients with inadequate clinical data.

Treatment and study plan

immunohistochemical expression of Cyclin D1 on oral squamous cell carcinoma tissue sections

Biological

Primary outcomes

immunohistochemical expression of Cyclin D1 in Oral Squamous Cell Carcinoma

Time frame: 6 months

detection of both intensity staining and tumor cells percentage of Cyckin D1 in studied cases of Oral Squamous Cell Carcinoma, and then relate intensity and percentage of Cyclin D1 with patients' ages, sexes, tumor grade, tumor site , lymphovascular invasion and perineural invasion.

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Important dates

Study start: 2017
Primary completion: 2025
Study completion: 2026
First posted: Aug 21, 2026
Registry last updated: Aug 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed