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NCT Number: NCT07777159

Carotid Doppler Changes After Passive Leg Raising for Prediction of Post-Induction Hypotension in Gastrointestinal Tumor Surgery

This prospective study aims to investigate the role of the passive leg raise maneuver prior to anesthesia induction in predicting post-induction hypotension among elective gastrointestinal tumor surgery patients using carotid artery Doppler parameters.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

The study will be conducted on patients scheduled for elective gastrointestinal tumor surgery. Prior to anesthesia induction, a passive leg raise maneuver will be performed. Carotid artery Doppler parameters and hemodynamic changes will be measured and recorded to evaluate their efficacy in predicting subsequent post-induction hypotension.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Patients scheduled for elective gastrointestinal tumor surgery
  • Surgery planned under general anesthesia
  • Body mass index (BMI) <40 kg/m²
  • Written informed consent provided

Exclusion criteria

  • Refusal to participate or inability to obtain written informed consent
  • BMI ≥40 kg/m²
  • Pregnancy
  • Emergency surgery
  • Difficult intubation
  • ASA physical status ≥IV
  • Pediatric patients (<18 years)
  • Inability to perform carotid Doppler measurements
  • Arrhythmia other than continuous sinus rhythm or uncontrolled cardiac arrhythmia
  • Severe cardiac dysfunction or left ventricular ejection fraction <40%
  • Severe valvular heart disease
  • Clinically significant autonomic nervous system disorders
  • Inadequate noninvasive blood pressure monitoring or inability to obtain the required hemodynamic measurements
  • Active sepsis or systemic inflammatory syndrome
  • Severe peripheral vascular disease or significant carotid artery stenosis (>50%)
  • Severe pulmonary disease or advanced respiratory failure
  • Implanted cardiac device (pacemaker/ICD)
  • Baseline mean arterial pressure (MAP) <65 mmHg
  • Preoperative systolic blood pressure >190 mmHg or diastolic blood pressure >110 mmHg

Treatment and study plan

Primary outcomes

  1. Predictive performance of dynamic changes in carotid Doppler parameters (ΔVTI, ΔPSV, ΔFTc) for post-induction hypotension

    Time frame: From pre-induction passive leg raising assessment to 20 minutes after general anesthesia induction

    Evaluation of the predictive performance of percentage changes in carotid artery velocity time integral (ΔVTI), peak systolic velocity (ΔPSV), and corrected flow time (ΔFTc) after passive leg raising maneuver for post-induction hypotension

Secondary outcomes

  1. Association of baseline carotid Doppler parameters with post-induction hypotension

    Time frame: From pre-induction assessment to 20 minutes after general anesthesia induction

    Evaluation of the association between baseline carotid Doppler parameters (VTI, PSV, and FTc) and the development of post-induction hypotension.

  2. Cut-off values of changes in carotid Doppler parameters for prediction of post-induction hypotension

    Time frame: From pre-induction passive leg raising assessment to 20 minutes after general anesthesia induction

    Determination of the optimal cut-off values of ΔVTI, ΔPSV, and ΔFTc for predicting post-induction hypotension.

  3. Association of carotid Doppler changes with duration and severity of hypotension

    Time frame: From general anesthesia induction to 20 minutes post-induction

    Evaluation of the association between ΔVTI, ΔPSV, and ΔFTc and the duration and severity of post-induction hypotension.

  4. Association of carotid Doppler changes with vasopressor requirement

    Time frame: From general anesthesia induction to 20 minutes post-induction

    Evaluation of the association between ΔVTI, ΔPSV, and ΔFTc and the requirement for vasopressor treatment after anesthesia induction.

Study contacts

Contact information is provided by the study sponsor or research team.

Seçilnaz Ünlü Tuncer, MD

CONTACT

[email protected]

+90 553 177 36 18

Sponsors and collaborators

Lead sponsor

Ankara City Hospital Bilkent

Other

Registry information

Official study title

Dynamic Changes in Carotid Artery Doppler Parameters Following Passive Leg Raising for Prediction of Post-Induction Hypotension in Patients Undergoing Elective Gastrointestinal Tumor Surgery

Acronym: PLR

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 20, 2026
Registry last updated
Aug 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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