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Completed

NCT Number: NCT07773324

Kinesio Taping After Platelet-Rich Plasma Treatment in Individuals With Knee Osteoarthritis

This randomized controlled study evaluated whether kinesio taping provided additional benefits compared with sham taping in women with knee osteoarthritis who had received platelet-rich plasma (PRP) treatment as part of routine clinical care. Sixty women aged 50 to 65 years with Kellgren-Lawrence grade 1 to 3 knee osteoarthritis were randomly assigned in a 1:1 ratio to either kinesio taping or sham taping. Taping was applied once weekly for 6 weeks. Participants were assessed before taping and at weeks 3, 6, and 12. Outcomes included pain, function, physical performance, knee extensor strength, knee range of motion, and quality of life. The study aimed to determine whether kinesio taping after PRP treatment was more effective than sham taping in improving pain, function, physical performance, knee extensor strength, knee range of motion and quality of life.

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Key information

Conditions

Osteoarthritis (OA) of the Knee Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Rheumatic Diseases

Age range

50 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Kafkas University Health Research and Application Hospital

Kars, 36100, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Female participants aged 50 to 65 years
  • Diagnosis of unilateral or bilateral knee osteoarthritis according to the American College of Rheumatology criteria
  • Kellgren-Lawrence radiographic grade 1 to 3 knee osteoarthritis
  • Received three platelet-rich plasma injections at 3-week intervals as part of routine clinical care
  • Ability to walk without an assistive device
  • Body mass index below 35 kg/m²
  • Willingness to participate and provision of written informed consent

Exclusion criteria

  • Knee surgery within the previous 6 months
  • Intra-articular injection other than platelet-rich plasma within the previous 3 months
  • Systemic inflammatory joint disease, including rheumatoid arthritis, ankylosing spondylitis, or gout
  • Known allergy or adverse skin reaction to kinesio tape
  • Skin condition preventing tape application, including skin sensitivity or an open wound
  • Neuromuscular disease causing lower-extremity muscle weakness
  • Perceptual or coordination impairment

Treatment and study plan

Kinesio Taping

Other

Therapeutic kinesio taping was applied once weekly for 6 weeks. A Y-cut tape was applied over the quadriceps muscle with 20% to 25% tension. Two web-cut tapes were applied around the knee with 10% to 15% tension. Each application remained in place for 5 days.

Sham Taping

Other

Sham taping was applied once weekly for 6 weeks. Two strips of tape were placed transversely 10 cm and 20 cm above the superior border of the patella without tape tension or a specific kinesio taping technique. Each application remained in place for 5 days.

Primary outcomes

  1. Knee Pain Intensity

    Time frame: Baseline and Weeks 3, 6, and 12

    Knee pain was assessed using an 11-point Numerical Rating Scale ranging from 0 (no pain) to 10 (worst imaginable pain). Higher scores indicate greater pain intensity.

  2. Function ((Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC))

    Time frame: Baseline and Weeks 3, 6, and 12

    Knee pain, stiffness, and physical function were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The pain, stiffness, and physical function subscale scores range from 0 to 20, 0 to 8, and 0 to 68, respectively. The total score ranges from 0 to 96. Higher scores indicate worse pain, stiffness, and functional limitation.

Secondary outcomes

  1. 30-Second Chair Stand Test

    Time frame: Baseline and Weeks 3, 6, and 12

    Functional performance was assessed using the 30-Second Chair Stand Test. The number of complete stands performed from a 44-cm-high chair within 30 seconds was recorded. A higher number of completed stands indicates better functional performance.

  2. 40-Meter Fast-Paced Walk Test

    Time frame: Baseline and Weeks 3, 6, and 12

    Functional walking performance was assessed using the 40-Meter Fast-Paced Walk Test. The time required to complete a total distance of 40 meters was recorded in seconds. A shorter completion time indicates better walking performance.

  3. 9-Step Stair Test

    Time frame: Baseline and Weeks 3, 6, and 12

    Stair performance was assessed by recording the time required to ascend and descend 9 steps as quickly and safely as possible without assistance. The completion time was recorded in seconds. A shorter time indicates better functional performance.

  4. Knee Extensor Strength

    Time frame: Baseline and Weeks 3, 6, and 12

    Maximal isometric knee extensor muscle strength was measured using a hand-held dynamometer with the hip and knee positioned at 90 degrees of flexion. Three measurements were performed, and the mean value was recorded in kilograms. Higher values indicate greater muscle strength.

  5. Knee Flexion Range of Motion

    Time frame: Baseline and Weeks 3, 6, and 12

    Active knee flexion range of motion was measured using a universal goniometer. Three measurements were performed, and the mean value was recorded in degrees.

  6. Knee Extension Range of Motion

    Time frame: Baseline and Weeks 3, 6, and 12

    Active knee extension range of motion was measured using a universal goniometer. Three measurements were performed, and the mean value was recorded in degrees.

  7. Change in 36-Item Short Form Health Survey (SF-36) Domain Scores

    Time frame: Baseline and Weeks 3, 6, and 12

    Quality of life was assessed using the 36-Item Short Form Health Survey (SF-36). The instrument evaluates eight domains: physical functioning, physical role limitations, emotional role limitations, emotional well-being, social functioning, energy/fatigue, bodily pain, and general health. Each domain is scored from 0 to 100, with higher scores indicating better health-related quality of life.

Sponsors and collaborators

Lead sponsor

Agri Ibrahim Cecen University

Other

Registry information

Official study title

The Efficacy of the Combined Use of Platelet-Rich Plasma and Kinesio Taping in Individuals With Knee Osteoarthritis: A Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 19, 2026
Registry last updated
Aug 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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