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NCT Number: NCT07773155

Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

The purpose of this study is to learn about the effectiveness of different pain control options after hand and wrist surgery, specifically Ketorolac, Tylenol, and a regional nerve block. Ketorolac (Toradol) is a nonsteroidal anti-inflammatory drug (NSAID) that is similar to ibuprofen (Motrin or Advil). Tylenol (acetaminophen) is a commonly used over the counter drug. A nerve block is pain medication that is applied directly to the nerves around the surgical site before the surgery and keeps working to reduce pain in the area for several hours after the surgery. All of these medicines and procedures are approved by the Food and Drug Administration (FDA) for patient care. This study aims to understand if using these medicines in combination helps patients having hand and wrist surgery avoid the need for opioid pain medications.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

University of Chicago

Chicago, Illinois, 60637, United States

Location status: Recruiting

About this study

Participants will be enrolled in two sequential groups:

  • The first group will be consented for a post-operative pain control regimen consisting of an intraoperative regional nerve block and 3 days of round-the-clock oral ketorolac, plus prescription strength acetaminophen as needed. These analgesic elements are standard of care for patients undergoing the procedures of interest, as an alternative to opioid use, though subjects of this study will be asked to use them as first-line therapy and receive other medications only for breakthrough pain.
  • The second group will be consented for a post-operative pain control regimen consisting of a standard care regimen of intraoperative regional nerve block and 3 days of round-the-clock opioids.

Patients in both groups will be asked to complete surveys in which they rate their pain score and describe what medications they have taken for pain.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years or older
  • Undergoing upper extremity surgery performed by a hand and upper extremity orthopaedic surgeon at the University of Chicago.
  • Undergoing procedure with regional nerve block

Exclusion criteria

  • Age less than 18 years
  • Concomitant chronic opioid use
  • Postoperative opioid use (surgery through POD 14) for condition other than repaired fracture
  • Medical contraindication to ketorolac use, including pregnancy
  • Undergoing multiple concurrent surgical procedures
  • Unable to communicate numerical pain score

Treatment and study plan

Toradol

Drug

Regional Nerve Block + Toradol + Acetaminophen

Oxycodone

Drug

Regional Nerve Block + Oxycodone + Acetaminophen

Primary outcomes

  1. Postoperative Pain, as measured by the Numeric Pain Scale

    Time frame: 2 days, 1 week and 2 weeks post op

    The numerical pain rating scale is used for rating postoperative pain. Pain scores rate from 0 to 10, with higher scores indicating more severe pain.

Secondary outcomes

  1. Opioid requirements, measured in oral morphine equivalents

    Time frame: Through 2 weeks postop

    Opioid requirements for breakthrough pain will be measured in Ketorolac (Toradol) group in Oral Morphine Equivalents (OME).

Study contacts

Contact information is provided by the study sponsor or research team.

Jennifer Wolf, MD

CONTACT

[email protected]

773-795-3583

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Registry information

Official study title

A Pilot Study to Assess Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Aug 19, 2026
Registry last updated
Aug 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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