Faculty of Dentistry, Cairo University
Cairo, Cairo Governorate, Egypt
Location contact
Manal Hosni
SUB_INVESTIGATOR
Maryam Alabbas, BDS
CONTACT
Maryam Alabbas, BDS
PRINCIPAL_INVESTIGATOR
Not yet recruiting
NCT Number: NCT07771257
Polynucleotide-Hyaluronic Acid Gel With Xenograft for Alveolar Ridge Preservation
This randomized controlled clinical trial will evaluate the efficacy of polynucleotide-hyaluronic acid gel combined with xenograft and collagen membrane for alveolar ridge preservation following tooth extraction. Twenty participants will be randomly allocated into two parallel groups. The test group will receive xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane, while the control group will receive xenograft with a collagen membrane alone. Clinical and CBCT assessments will be performed at baseline and during follow-up. After 6 months, ridge dimensional changes will be evaluated and core biopsies will be obtained at the time of implant placement for histological assessment.
Not yet recruiting
Trial opening soon.
Get NotifiedKey information
Conditions
Age range
18 year–60 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Patients aged 18-60 years.
- Patients free from systemic diseases affecting wound healing or bone regeneration or contraindicating oral surgery.
- Non-smokers with good oral hygiene.
- Patients requiring tooth extraction in non-infected sockets due to endodontic failure, non-restorable caries, or trauma, and who will receive implant treatment.
- Class I extraction sockets with intact alveolar bone walls.
- Presence of teeth adjacent to the extraction site.
Exclusion criteria
- Use of drugs affecting wound healing.
- Heavy smokers (>10 cigarettes/day) or history of substance abuse.
- Pregnant or breastfeeding women.
- Previous grafting or surgical intervention in the study area.
- Uncontrolled and/or untreated periodontal disease (active periodontitis).
- Mentally or physically handicapped patients.
Treatment and study plan
Polynucleotide-Hyaluronic Acid Gel With Xenograft
OtherXenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane for alveolar ridge preservation after tooth extraction.
Xenograft With Collagen Membrane
OtherXenograft placed in the extraction socket and covered with a collagen membrane for alveolar ridge preservation after tooth extraction.
Primary outcomes
-
Change in Buccal Bone Plate Height
Time frame: Baseline and 6 months
The height of the buccal bone plate will be measured using digital superimposition of Cone Beam Computed Tomography (CBCT) scans obtained at baseline and 6 months. Measurements will be recorded in millimeters
Secondary outcomes
-
Change in Palatal Bone Plate Height
Time frame: Baseline and 6 months
The height of the palatal bone plate will be measured using digital superimposition of Cone Beam Computed Tomography (CBCT) scans obtained at baseline and 6 months. Measurements will be recorded in millimeters.
-
Change in Horizontal Ridge Width
Time frame: Baseline and 6 months
Horizontal ridge width will be measured using digital superimposition of Cone Beam Computed Tomography (CBCT) scans at 2 mm, 4 mm, and 6 mm below the most coronal aspect of the alveolar crest. Measurements will be compared between baseline and 6 months and recorded in millimeters.
-
Percentage of New Vital Bone Formation
Time frame: 6 months
The percentage of newly formed vital bone will be assessed histologically and histomorphometrically in core biopsy specimens obtained from the preserved site at the time of implant placement after 6 months.
-
Percentage of Residual Graft Particles
Time frame: 6 months
The percentage of residual graft particles will be assessed histologically and histomorphometrically in core biopsy specimens obtained from the preserved site at the time of implant placement after 6 months.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Cairo University
Other
Registry information
Official study title
Evaluation of the Efficacy of Polynucleotide-Hyaluronic Acid Gel With Xenograft Compared to Xenograft Alone in Alveolar Ridge Preservation: A Randomized Clinical Trial
Important dates
- Study start
- 2026
- Primary completion
- 2027
- Study completion
- 2027
- First posted
- Aug 18, 2026
- Registry last updated
- Aug 18, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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