Effects of N-Acyl Taurines on Incretin Levels in Healthy Subjects

Inclusion criteria

• Age between 18 and 45 years
• Body mass index between 18.5-27 kg/m2
• Informed consent
• Weight stable in the past 3 months

Exclusion criteria

• Regular tobacco smoking or use of other nicotine-containing products
• Allergy or intolerance to ingredients included in the test compounds or standardised meals
• Glycated haemoglobin (HbA1c) >48 mmol/mol
• Anaemia (haemoglobin below 8.3 mmol/L)
• Alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) >2 times upper normal values (Normal values: ALT < 70 U/L, AST <45 U/L)
• Nephropathy (eGFR<90mL/min/1.73 m2) and/or albuminuria (>30 mg/g albumin in urine))
• Women of childbearing potential who are not using effective contraception
• Pregnancy or breastfeeding
• History of hepatobiliary or gastrointestinal disorder(s)
• Use of weight loss medication within the last 6 months
• Any physical or psychological condition, or ongoing medication, that the investigator evaluates would interfere with trial participation, including any acute or chronic illnesses