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NCT Number: NCT07769944

Ultrasound Biomicroscopic Assessment of Intraocular Lens Tilt and Decenteration After Phacoemulsification

This study aims to assess intraocular lens (IOL) tilt and decenteration by means of ultrasound biomicroscopy after phacoemulsification.

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Key information

Conditions

Ultrasound Biomicroscopy Decenteration Intraocular Lens Phacoemulsification Tilt

Age range

Up to 45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag University

Sohag, Sohag Governorate, 82511, Egypt

Location status: Recruiting

Location contact

Alaa A Ahmed, MD

SUB_INVESTIGATOR

Amr M Mohammed, MD

SUB_INVESTIGATOR

Mennatullah A Farrag, MBBCH

CONTACT

[email protected]

00201129595307

Mohamed A Abdellatif, MD

SUB_INVESTIGATOR

About this study

Ultrasound biomicroscopy (UBM) is a non-invasive technique that uses high-frequency ultrasound to image the anterior segment of the eye.

It can help as a diagnostic procedure in eyelid and anterior segment (cornea, conjunctiva, sclera, iris, ciliary body) pathology. It is a vital tool in evaluating anterior segment cysts or tumors and their diagnosis, evolution, and treatment.

IOL tilt and decentration could be secondary to various aetiologies. The extent and direction of preoperative crystalline lens tilt have been demonstrated to be strongly correlated with postoperative tilt. Asymmetrical IOL fixation (partly in bag and partly in sulcus) and capsular tear during capsulorrhexis were reported as some causative factors to IOL tilt and decentration.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both sexes.
  • Patients with senile cataract prepared for phacoemulsification and IOL implantation.

Exclusion criteria

  • Age <45 years.
  • Complicated ataract.
  • Coexisting ocular disorders (Glaucoma, Pseudoexfoliation Syndrome, Sublaxation, Chronic Iridocyclitis).
  • Previous ocular surgery.
  • Complicated phacoemulsification.

Treatment and study plan

Ultrasound biomicroscopy

Device

Scanning is conducted with the non-dilated eye in a central position and the patient in the supine position. A drop of a topical anesthetic agent (benoxinate hydrochloride) is applied to both eyes.

Primary outcomes

  1. Measurement of intraocular lens tilt

    Time frame: Six months after surgery

    Measurement of intraocular lens (IOL) tilt. The intraocular lens (IOL) position was measured as the Anterior Chamber Depth (ACD), defined as the distance between the anterior border of the hyperreflective line marking the central posterior corneal surface and the anterior IOL optic surface at the centre of the pupillary space.

Secondary outcomes

  1. Measurement of intraocular lens decenteration

    Time frame: Six months after surgery

    Anterior Chamber Depth (ACD) was determined from the central inner corneal surface, perpendicular to the corneal surface to the most anteriorly visible part of the intraocular lens (IOL). A line (line AB) was drawn between the two scleral spurs (SSs), as the base line of reference for IOL position. Two perpendicular lines were drawn from both optical endpoints of the IOL (C and D) to the base line with intersection points (E and F). IOL decentration was equal to half of the differences between distance AE and FB, i.e. IOL decentration = (|AE-FB|) / 2.

Study contacts

Contact information is provided by the study sponsor or research team.

Mennatullah A Farrag, MBBCH

CONTACT

[email protected]

00201129595307

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 18, 2026
Registry last updated
Aug 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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