AngioVac Aspiration Therapy Registry

The AngioVac Aspiration System is a percutaneous device that enables removal of intravascular and intracardiac thrombotic or infectious material using a venovenous extracorporeal circuit with blood filtration and reinfusion. The system combines:

• Direct aspiration of thrombi or vegetations
• In-line blood filtration (protecting distal circulation)
• Lower embolic risk compared to surgical extraction

The AngioVac applications include the following clinical situations:

• CIED-Related Pathology: Lead-associated thrombus and vegetations during cardiac implantable electronic device (CIED) extraction
• Infective Endocarditis: Right-sided infective endocarditis with large vegetations
• Venous Thrombosis: Central venous thrombi (SVC, IVC, iliofemoral) and right atrial/ventricular thrombi
• Pulmonary Artery: Acute pulmonary artery thrombotic material
• Malignancy-Associated: Cancer-associated thrombosis and catheter-associated thrombi

Despite increasing clinical adoption, the evidence base remains limited:

• Majority of published data consist of single-center case series with small cohorts
• Heterogeneous reporting of outcomes, definitions, and complications across studies
• Limited head-to-head comparisons with alternative interventions
• Insufficient data on safety across diverse indications and patient phenotypes
• Predictive factors for success and complications remain poorly characterized

Inclusion criteria

• Age ≥18 years at time of AngioVac procedure
• Patient underwent percutaneous AngioVac aspiration (any AngioVac model or version used clinically during study period)
• Procedure performed within study period (January 2018 (or site's institutional start date) - June 2026)
• Written informed consent OR documented waiver/exemption from ethics authority (per local regulations per GDPR)

Exclusion criteria

• Insufficient documentation to assess primary safety or effectiveness endpoints (e.g. defined as >20% missing data in core endpoint variables)
• Patient objection to retrospective data use (where required by local law; GDPR Article 21 opt-out; honored without study impact)
• Non-AngioVac procedures: Patients undergoing thrombus/vegetation removal by surgery or other percutaneous devices only (not AngioVac)