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NCT Number: NCT07769203

Effects of MET and MFR on Piriformis Syndrome

The aim of this study is to comparatively evaluate the effects of two different manual therapy approaches, Muscle Energy Technique (MET) and Myofascial Release Technique (MFR), on pain threshold, muscle activation patterns, and muscle strength in individuals diagnosed with piriformis syndrome.

In this study, the physiological effects of both interventions on the musculoskeletal system will be assessed using objective measurement tools such as an algometer, digital dynamometer, and electromyography (EMG). The study aims to provide evidence-based data regarding the most effective and preferable manual therapy approach in the conservative treatment of piriformis syndrome.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Participants included in the study will complete the Sociodemographic Information Form, Oswestry Disability Index (ODI), Lower Extremity Functional Scale (LEFS), World Health Organization Quality of Life Scale Brief Form (WHOQOL-BREF), Pittsburgh Sleep Quality Index (PSQI), and the Short-Form McGill Pain Questionnaire (SF-MPQ).

Additionally, participants will undergo the 6-Minute Walk Test (6MWT). Lower extremity muscle strength will be evaluated using a digital dynamometer, pain threshold will be assessed with an algometer, and muscle activation patterns will be evaluated using surface electromyography (sEMG) in the FAIR position.

The entire assessment procedure will take approximately 30-40 minutes, and all measurements will be performed under standardized conditions by the same researcher.

This study is a randomized controlled experimental trial aiming to compare the effects of two different manual therapy approaches, Muscle Energy Technique (MET) and Myofascial Release Technique (MFR), on pain threshold, muscle activation patterns, and muscle strength in individuals diagnosed with piriformis syndrome.

The study is designed as a pretest-posttest trial. Participants will be randomly allocated into three groups: the MET group, the MFR group, and the control group. All groups will receive treatment for 8 weeks, with 2 sessions per week, totaling 16 treatment sessions.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Individuals diagnosed with piriformis syndrome
  • Presence of piriformis tenderness and sciatic symptoms
  • Aged between 18 and 65 years
  • Voluntary agreement to participate in the study
  • No history of lumbar, hip, knee, or ankle surgery within the last year
  • Ability to cooperate with the assessment and treatment procedures

Exclusion criteria

  • Individuals younger than 18 years or older than 65 years
  • Presence of any musculoskeletal disorder affecting the lower extremity
  • Presence of neurological, cardiac, pulmonary, or orthopedic disorders preventing participation in exercise
  • Presence of neurological deficits (muscle strength loss)
  • History of radiotherapy to the lumbar or hip region
  • Absence from more than 20% of treatment sessions
  • Inability to comply with the study procedures (e.g., cognitive impairment, communication problems, severe psychiatric disorders)
  • Corticosteroid or PRP injection within the last 3 months
  • Participation in another physical therapy program within the last 3 months
  • Use of analgesic, anti-inflammatory, or muscle relaxant medications within the last 48-72 hours
  • Use of psychotropic medications that may affect muscle activation or nervous system responses (e.g., antidepressants, antipsychotics, sedatives)

Treatment and study plan

muscle energy technique

Procedure

Muscle Energy Technique (MET) will be applied to participants by a trained physiotherapist in addition to conventional physical therapy. The intervention will be performed for 8 weeks, 2 sessions per week, totaling 16 sessions. The technique will include voluntary muscle contractions followed by relaxation and stretching procedures targeting the piriformis muscle.

Myofascial release technique

Procedure

Myofascial Release Technique (MFR) will be applied to participants by a trained physiotherapist in addition to conventional physical therapy. The intervention will be performed for 8 weeks, 2 sessions per week, totaling 16 sessions. The technique will involve sustained manual pressure and soft tissue release techniques targeting the piriformis muscle and surrounding fascia.

Conventional Physical Therapy

Procedure

Participants in the control group will receive conventional physical therapy for 8 weeks, 2 sessions per week, totaling 16 sessions.

Primary outcomes

  1. Pressure Pain Threshold

    Time frame: Baseline and after 8 weeks of treatment

    Assessment of pressure pain threshold using an algometer.

Secondary outcomes

  1. Pain Severity (SF-MPQ)

    Time frame: Baseline and after 8 weeks of treatment

    Pain intensity and pain characteristics will be evaluated using the Short-Form McGill Pain Questionnaire (SF-MPQ). Higher scores indicate greater pain severity.

  2. Muscle Strength

    Time frame: Baseline and after 8 weeks of treatment

    Assessment of lower extremity muscle strength using a digital dynamometer.

  3. Muscle Activation Pattern

    Time frame: Baseline and after 8 weeks of treatment

    Assessment of muscle activation patterns using surface electromyography (sEMG) in the FAIR position.

  4. Lower Extremity Functional Scale (LEFS)

    Time frame: Baseline and after 8 weeks of treatment

    Assessment of lower extremity functional status using the Lower Extremity Functional Scale (LEFS).

  5. Oswestry Disability Index (ODI)

    Time frame: Baseline and after 8 weeks of treatment

    Assessment of disability level using the Oswestry Disability Index (ODI).

  6. World Health Organization Quality of Life Scale Brief Form (WHOQOL-BREF)

    Time frame: Baseline and after 8 weeks of treatment

    Assessment of quality of life using the World Health Organization Quality of Life Scale Brief Form (WHOQOL-BREF).

  7. Sleep Quality (PSQI)

    Time frame: Baseline and after 8 weeks of treatment

    Assessment of sleep quality using the Pittsburgh Sleep Quality Index (PSQI).

  8. 6-Minute Walk Test

    Time frame: Baseline and after 8 weeks of treatment

    Assessment of functional exercise capacity using the 6-Minute Walk Test (6MWT).

Study contacts

Contact information is provided by the study sponsor or research team.

Nuran Akdağ Mirzaoğlu, Msc/PT/Lecture

CONTACT

[email protected]

+905058179557

Yavuz Yakut, Prof. Dr.

CONTACT

[email protected]

+905324181001

Sponsors and collaborators

Lead sponsor

Igdir University

Other

Registry information

Official study title

The Effect of Muscle Energy Technique and Myofascial Release Technique on Pain Threshold, Muscle Activation Pattern, and Muscle Strength in Piriformis Syndrome

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 17, 2026
Registry last updated
Aug 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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