Characterization of Skin Changes (Clinical, Physiological, and Pathological) From the Use of Moisturizers in Participants With Cancer Experiencing Dermatological Adverse Events

Change in patient-reported skin dryness severity from baseline to follow-up visit (2-4 weeks) as measured by validated dryness severity scale (0-10 numerical rating scale where 0 = no dryness and 10 = severe dryness).

The time from baseline to the first documented improvement in dryness symptoms, defined as either a ≥2-point reduction in dryness severity score from baseline or patient-reported meaningful improvement in dryness symptoms, whichever occurs first. Lower values indicate a faster improvement in symptoms.

Change in skin hydration from baseline to follow-up, measured using corneometry and reported in corneometry units (CU). Higher corneometry values indicate greater stratum corneum hydration. Positive changes from baseline reflect improved skin hydration, whereas negative changes indicate reduced hydration.

Change in skin barrier function from baseline to follow-up, measured by transepidermal water loss (TEWL) and reported in g/h/m². TEWL quantifies the amount of water that passively evaporates through the skin. Lower TEWL values indicate improved skin barrier integrity and reduced water loss, while higher values indicate increased barrier disruption. Negative changes from baseline reflect improvement, whereas positive changes indicate worsening skin barrier function.