Blood and Cystic Fluid From Patients Undergoing Surgery for Worrisome Pancreatic Cysts

The goal of this study is to collect biospecimens (blood and cystic fluid) and data from participants who have a pancreatic cyst that requires surgical resection. The blood and fluid samples will be analyzed for research into DNA, RNA, and proteins.

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Key information

Conditions

Pancreatic Cyst Cysts Digestive System Diseases Neoplasms Pancreatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hoag Family Cancer Institute, Newport Beach, California, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Voluntarily agree to participate by giving written informed consent prior to any study-specific procedures.
Subject at least 18 years of age and able to provide consent. Subject is willing and able to comply with requirements of the protocol.
Radiologically documented cyst of the pancreas for which surgical removal is clinically indicated.
Patient will be undergoing a surgical resection of their pancreatic cystic neoplasm.

Exclusion criteria

Patient who is pregnant at the time of study enrollment and sample collection.
Patient will not be undergoing clinically indicated surgery for a pancreatic cystic neoplasm.
Patient is unwilling or unable to provide informed consent or comply with study procedures.

Treatment and study plan

Primary outcomes

Characterize the miRNA and protein signatures in exosomes derived from blood and cyst fluids in patients with worrisome cystic pancreatic tumors

Time frame: At enrollment

Study contacts

Contact information is provided by the study sponsor or research team.

Michael Demeure, MD

CONTACT

[email protected]

949-764-4577

Sponsors and collaborators

Lead sponsor

Translational Genomics Research Institute

Other

Collaborators

City of Hope National Medical Center
Hoag Memorial Hospital Presbyterian
Piedmont Healthcare

Registry information

Official study title

Pilot Proof of Concept Study of miRNA and Protein Signatures in Exosomes From Blood and Cystic Fluid in Patients Undergoing Surgery for Worrisome Pancreatic Cysts

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2028
First posted: Aug 17, 2026
Registry last updated: Aug 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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