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Completed

NCT Number: NCT07766564

A Clinical Trial to Evaluate the Effects of Two Supplements on Cognitive Function, Cognitive Performance, and Mood

This study evaluates the effects of two liquid dietary supplements, BrainJuice Peach Mango (test product one) and BrainJuice ACTIVE Pomegranate Acai (test product two), on cognitive function, cognitive performance, and mood in healthy adults aged 18-57 who report concerns in these areas. The trial is a six-week, single-arm, open-label, virtual study enrolling 30 participants.

Participants will consume test product one (2.5 oz once daily) during Weeks 1 and 2, undergo a washout period during Weeks 3 and 4, and then consume test product two (2.5 oz once daily) during Weeks 5 and 6. Cognitive function will be assessed via standardized computerized cognitive assessments at Baseline, Week 2, Week 4, and Week 6, while perceptions of cognitive function, cognitive performance, and mood will be captured through self-reported questionnaires at Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6.

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Key information

Conditions

Cognitive Function Cognitive Performance Mood

Age range

18 year–57 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Citruslabs

Las Vegas, Nevada, 89101, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be male or female
  • Be aged 18-57
  • Anyone experiencing concerns regarding all of the following over the past four weeks: Cognitive Function, Cognitive Performance, and Mood
  • Anyone who is generally healthy - does not live with any uncontrolled chronic disease
  • If taking oral over-the-counter supplements or herbal remedies targeted at cognitive function, cognitive performance, or mood, has been consistently taking these for at least 3 months prior to starting the study, and is willing to maintain this routine for the study duration
  • Anyone who is a regular caffeine consumer without a history of caffeine sensitivity or intolerance
  • Willing to maintain the same diet and exercise regimen consistently throughout the study duration
  • Willing to limit caffeine consumption to one additional serving of caffeine outside of the test product i.e. one cup of brewed coffee (~100 mg), one matcha (~60 mg), two shots of espresso (~120 mg), or one cup of caffeinated tea (~50 mg)
  • Resides in the United States
  • Has access to a computer or tablet device

Exclusion criteria

  • Anyone with pre-existing chronic conditions, including but not limited to oncological, uncontrolled hypertension (high blood pressure) or hypotension (low blood pressure), heart disease, diabetes and psychiatric disorders
  • History of neurodegenerative disease (e.g., Alzheimer's, Parkinson's), history of traumatic brain injury (including concussions), stroke, epilepsy, or uncontrolled migraine
  • History of mood disorders, such as depression, bipolar disorder, or seasonal affective disorder
  • History of sleep disorders, such as insomnia, narcolepsy, or sleep apnea
  • Anyone with a job that involves shift work that may be overnight or night hours
  • Planning on introducing any products or any new forms of prescription medication or supplements that target cognitive function, cognitive performance, or mood, for the study duration
  • Anyone with any allergies or sensitivities to any of the study product ingredients
  • Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period)
  • Anyone unwilling to follow the study protocol
  • Anyone with a history of substance abuse
  • Anyone who is currently a smoker or has been a smoker in the past 3 months
  • Currently partaking in another research study or will be partaking in any other research study at any point during this study's duration

Treatment and study plan

BrainJuice Supplement

Dietary Supplement

All participants consume BrainJuice Peach Mango (test product one, 2.5 oz once daily) during Weeks 1 and 2, followed by a washout period during Weeks 3 and 4 with no test product, followed by BrainJuice ACTIVE Pomegranate Acai (test product two, 2.5 oz once daily) during Weeks 5 and 6. There is no comparator or placebo arm.

Primary outcomes

  1. Change in Cognitive Assessment Score (Polygons)

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Mean change in Polygons processing test score from Baseline, measured via computerized cognitive assessment

  2. Change in Cognitive Assessment Score (Double Trouble)

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Mean change in Double Trouble selective attention and processing speed test score from Baseline, measured via computerized cognitive assessment

  3. Change in Cognitive Assessment Score (Feature Match)

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Mean change in Feature Match focus and processing test score from Baseline, measured via computerized cognitive assessment

  4. Change in Cognitive Assessment Score (Paired Associates)

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Mean change in Paired Associates memory task score from Baseline, measured via computerized cognitive assessment

  5. Change in Cognitive Assessment Score (Digit Span)

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Mean change in Digit Span short-term memory and attention test score from Baseline, measured via computerized cognitive assessment

  6. Change in Cognitive Assessment Score (Spatial Planning)

    Time frame: Baseline, Week 2, Week 4, and Week 6

    Mean change in Spatial Planning executive function test score from Baseline, measured via computerized cognitive assessment

Secondary outcomes

  1. Change in Self-Reported Focus

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived focus from Baseline, assessed via self-reported questionnaire

  2. Change in Self-Reported Attention

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived attention from Baseline, assessed via self-reported questionnaire

  3. Change in Self-Reported Concentration

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived concentration from Baseline, assessed via self-reported questionnaire

  4. Change in Self-Reported Productivity

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived productivity from Baseline, assessed via self-reported questionnaire

  5. Change in Self-Reported Alertness

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived alertness from Baseline, assessed via self-reported questionnaire

  6. Change in Self-Reported Mental Clarity

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived mental clarity from Baseline, assessed via self-reported questionnaire

  7. Change in Self-Reported Mood

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived mood from Baseline, assessed via self-reported questionnaire

  8. Change in Self-Reported Mental Fatigue

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived mental fatigue from Baseline, assessed via self-reported questionnaire

  9. Change in Self-Reported Motivation

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived motivation from Baseline, assessed via self-reported questionnaire

  10. Change in Self-Reported Organization

    Time frame: Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6

    Mean change in perceived organization from Baseline, assessed via self-reported questionnaire

Sponsors and collaborators

Lead sponsor

BrainJuice

Industry

Collaborators

  • Citruslabs

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Aug 14, 2026
Registry last updated
Aug 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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