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NCT Number: NCT07766395

A Clinical Trial to Evaluate the Effects of a Powder Supplement in Supporting Lean Muscle Development, Hormone-Related Wellness, Digestive Comfort, Dermatologic Health, and Overall Wellness

This study will evaluate the effects of Clean Nutra's Shelf Builder Women's Creatine Powder on lean muscle development, hormone-related wellness, digestive comfort, dermatological health, and overall wellness. The study is a single-arm, open-label, virtual trial in which all 35 enrolled participants will use the test product once daily for eight weeks.

Participants will complete self-reported questionnaires at Baseline and at the end of Week 4 and Week 8 to assess changes in lean muscle development, muscular endurance, hormone-related wellness, digestive comfort, hair/nail/skin health, and overall wellness.

Recruiting

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Key information

Conditions

Lean Muscle Development Dermatologic Health Digestive Comfort Hormone-Related Wellness Muscular Endurance Overall Wellness

Age range

21 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Citruslabs

Las Vegas, Nevada, 89101, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be female.
  • Be aged 21-45.
  • Engages in structured physical activity ≥3 times per week, with each session lasting at least 30 minutes, (e.g., running, gym/strength training, cycling, team sports, fitness classes).
  • Anyone with a menstrual cycle between 24-38 days.
  • Anyone who has experienced concerns with at least two of the following, twice per week, over the past four weeks: Hair, skin, and nail health
  • Bloating
  • Symptoms of hormonal imbalance.
  • Anyone with a BMI of 18.5 to 30 kg/m2.
  • Anyone who is generally healthy - does not live with any uncontrolled chronic disease.
  • If taking medications, other supplements, or herbal remedies targeted at lean muscle development, muscular endurance, digestive comfort, hormonal balance, or dermatological health, has been consistently taking for at least three months prior to starting the study, and is willing to maintain this routine for the study duration.
  • Anyone who is willing to maintain their current diet, sleep pattern, and activity levels for the duration of the trial.
  • Resides in the United States.

Exclusion criteria

  • Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including oncological and mental health disorders.
  • Anyone with a known history of severe digestive disorders like acid reflux, Irritable Bowel Syndrome (IBS), Irritable Bowel Disease (IBD), Crohn's disease, or gastrointestinal tract surgeries.
  • Planning on introducing any products or any new forms of prescription medication or supplements that target lean muscle development, muscular endurance, digestive comfort, hormonal balance, or dermatological health for the study duration.
  • Anyone who has been diagnosed with kidney disease and/or has previously or is currently taking diuretics or kidney medications.
  • Anyone who has previously or is currently taking any hormone therapies.
  • Anyone who is currently taking medications or supplements that contain zinc or iron.
  • Anyone with any allergies or sensitivities to fish, eggs, or any of the study product ingredients.
  • Anyone currently consuming products with creatine.
  • Anyone diagnosed with a thyroid-related condition.
  • Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period).
  • Anyone who has a history of serious illness in the last three months.
  • Anyone who has planned surgery during the study period.
  • Anyone with a history of substance abuse.
  • Anyone who is currently a smoker or has been a smoker in the past 3 months.
  • Anyone who has stopped or started using hormonal birth control in the past 2 months.
  • Anyone who is vegan and/or does not consume animal products for any reason.
  • Anyone currently taking a weight loss medication, including but not limited to Wegovy, Mounjaro, and Ozempic.
  • Currently undergoing hair treatment or using other hair growth/thickening products.
  • Currently taking any prescription medication for hair loss.
  • Anyone with any conditions that affect the hair or scalp (e.g., alopecia areata).
  • Anyone who drinks heavily (8 or more alcoholic drinks per week).

Treatment and study plan

Shelf Builder Women's Creatine Powder

Dietary Supplement

All participants take one scoop (9 g) of Clean Nutra Shelf Builder Women's Creatine Powder mixed in 8 oz of cold water once daily with the first meal of the day for eight weeks.

Primary outcomes

  1. Change in Lean Muscle Development

    Time frame: Baseline, Week 4, and Week 8

    Self-reported change in lean muscle development assessed via questionnaire

  2. Change in Muscular Endurance

    Time frame: Baseline, Week 4, and Week 8

    Self-reported change in muscular endurance assessed via questionnaire

  3. Change in Digestive Comfort

    Time frame: Baseline, Week 4, and Week 8

    Self-reported change in digestive comfort assessed via questionnaire

  4. Change in Hair

    Time frame: Baseline, Week 4, and Week 8

    Self-reported change in hair, nail, and skin health assessed via questionnaire

  5. Change in Nail

    Time frame: Baseline, Week 4, and Week 8

    Self-reported change in hair, nail, and skin health assessed via questionnaire

  6. Change in Skin Health

    Time frame: Baseline, Week 4, and Week 8

    Self-reported change in hair, nail, and skin health assessed via questionnaire

  7. Change in Symptoms of Hormonal Imbalance

    Time frame: Baseline, Week 4, and Week 8

    Self-reported change in symptoms of hormonal imbalance assessed via questionnaire

  8. Change in Overall Health and Wellness

    Time frame: Baseline, Week 4, and Week 8

    Self-reported change in overall health and wellness assessed via questionnaire

Secondary outcomes

  1. Perceived Change in Lean Muscle Strength

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in lean muscle strength assessed via self-reported questionnaire

  2. Perceived Change in Exercise Performance

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in exercise performance assessed via self-reported questionnaire

  3. Perceived Change in Lean Muscle Development

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in lean muscle development assessed via self-reported questionnaire

  4. Perceived Change in Hair

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in hair, nail, and skin health assessed via self-reported questionnaire

  5. Perceived Change in Nail

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in hair, nail, and skin health assessed via self-reported questionnaire

  6. Perceived Change in Skin Health

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in hair, nail, and skin health assessed via self-reported questionnaire

  7. Perceived Change in Mood

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in mood assessed via self-reported questionnaire

  8. Perceived Change in Energy Levels

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in energy levels assessed via self-reported questionnaire

  9. Perceived Change in Mental Clarity

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in mental clarity assessed via self-reported questionnaire

  10. Perceived Change in Digestive Health

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in digestive health assessed via self-reported questionnaire

  11. Perceived Change in Bloating

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in bloating assessed via self-reported questionnaire

  12. Perceived Change in Digestive Comfort

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in digestive comfort assessed via self-reported questionnaire

  13. Perceived Change in Muscle Recovery

    Time frame: Baseline, Week 4, and Week 8

    Participant-perceived change in muscle recovery assessed via self-reported questionnaire

Study contacts

Contact information is provided by the study sponsor or research team.

Patrick Renner

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Clean Nutraceuticals

Industry

Collaborators

  • Citruslabs

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 14, 2026
Registry last updated
Aug 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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