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NCT Number: NCT07766356

Study of Cognitive-Linguistic Profiles: The Role of Executive Control in Aphasia

In France, stroke affects 150,000 people annually and is the leading cause of acquired disability in adults; 10-12% of patients exhibit mild post-stroke aphasia, a condition defined by language difficulties.

Few studies describe mild post-stroke aphasia, and none characterize the impairment of linguistic executive control in this population; consequently, its prevalence remains unknown. To date, the role of linguistic executive control in mild aphasia remains an open question.

The aim of this project is to investigate linguistic executive control impairment in stroke survivors with mild aphasia, provide an initial estimate of its prevalence, and demonstrate its interactions with other linguistic and communicative aspects, as well as with executive and attentional functions.

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Key information

Conditions

Stroke Aphasia Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Communication Disorders Language Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Speech Disorders Vascular Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Service de Médecine Physique et de Réadaptation Hôpital Raymonde Fournet Purpan

Toulouse, 31300, France

Location contact

Emeline MULLER

CONTACT

[email protected]

0561778707 ext. +33

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient who has experienced a first ischemic stroke resulting in clinical symptoms within the last 3 months and is receiving care in the Physical Medicine and Rehabilitation department.
  • Score ≤ 31 on the conversational speech observation scale of the MEC test (Montreal Protocol for the Evaluation of Communication).
  • Patients with a BDAE score ≥ 3 (Boston Diagnostic Aphasia Examination - French version, Mazaux J.-M. [1990]); this score is the gold standard in aphasiology.
  • Native French-speaking patient capable of understanding oral or written instructions.

Exclusion criteria

  • Patients exhibiting behavior or a clinical condition incompatible with test administration, as assessed by the clinician.
  • Known major visual, auditory, or motor impairments incompatible with test performance.
  • Known neurodegenerative and/or neurodevelopmental disorders.
  • Known social cognition disorders (e.g., ASD).

Treatment and study plan

Neuropsychological tests

Diagnostic Test

Patients undergo neuropsychological tests, the order of which will be randomized.

Speech-language assessments

Diagnostic Test

Patients will undergo speech-language assessments, with the order of the tests randomized.

Primary outcomes

  1. measure the proportion of patients with mild post-stroke aphasia exhibiting deficits in linguistic executive control within three months of a first stroke

    Time frame: 7 days after the inclusion

    CATEX score result (deficit score if below the mean value minus 1.65 times the standard deviation)

Secondary outcomes

  1. Study of the correlation between executive control of language (CATEX score) and the score of the test evaluating access to the lexical stock

    Time frame: 7 days after the inclusion

  2. Study of the correlation between linguistic executive control (CATEX score) and the score of the test evaluating access to the semantic system

    Time frame: 7 days after the inclusion

  3. Study of the correlation between linguistic executive control (CATEX score) and the score of the test evaluating non-verbal executive control

    Time frame: 7 days after the inclusion

  4. Study of the correlation between linguistic executive control (CATEX score) and the score of the test evaluating gnosies

    Time frame: 7 days after the inclusion

  5. Identification of patients' cognitive-linguistic impairment profiles based on cognitive test scores

    Time frame: 7 days after the inclusion

  6. Identification of patients' cognitive-linguistic impairment profiles based on stroke location using factor analysis

    Time frame: 7 days after the inclusion

Study contacts

Contact information is provided by the study sponsor or research team.

Elodie GUILLOUET

CONTACT

[email protected]

0561779072 ext. +33

Sponsors and collaborators

Lead sponsor

University Hospital, Toulouse

Other

Registry information

Official study title

Study of Cognitive-linguistic Profiles in Brain-injured Adults: the Role of Executive Control in Mild Aphasia.

Acronym: P-CLAC

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Aug 14, 2026
Registry last updated
Aug 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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