Skip to main content
OpenTrials
Not yet recruiting

NCT Number: NCT07765680

Perioperative Yoga Therapy and Endometriosis Surgery

YOGENDOCHIR is a multicentre, prospective, randomised, controlled, parallel-group study involving 188 adult women scheduled to undergo surgery for endometriosis.

The study compares standard surgical management alone with the same management combined with a structured perioperative yoga therapy programme comprising 32 guided sessions (16 before and 16 after surgery), supplemented by a secure digital platform supporting independent practice and adherence monitoring.

The primary objective is to assess the effect of yoga therapy on endometriosis-related pain, as measured by the pain subscale of the Endometriosis Health Profile-30 (EHP-30). Participants are assessed before surgery and at 3, 6, and 12 months after the procedure.

Secondary outcomes include quality of life, pain characteristics, fatigue, sleep, anxiety and depressive symptoms, sexual health, kinesiophobia, activities of daily living, medication use, healthcare utilisation, absenteeism, adherence, satisfaction, and the participants' ability to use the platform independently.

Not yet recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Endometriosis Chronic Pain Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Impairment of Quality of Life Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Urogenital Diseases

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

CHU de Lille

Lille, 59000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

  • Adult woman (18 years or older) covered by a social health insurance scheme.
  • Surgery for endometriosis is indicated.
  • No assisted reproductive technology (ART) protocol planned within 6 months after surgery.
  • No chronic pain attributable to another disease or condition.
  • No yoga practice outside the study during participation.

Treatment and study plan

Standard surgical management for endometriosis

Procedure

Participants undergo the indicated surgery for endometriosis and receive standard perioperative and follow-up care, without study yoga therapy sessions. They complete the same scheduled clinical and patient-reported assessments as the intervention group.

Structured perioperative yogatherapy programme plus standard surgical management

Procedure

Participants undergo the indicated surgery for endometriosis and receive 32 live, guided yoga therapy sessions: 16 sessions during the 2 months before surgery and 16 sessions during the 3 months after surgery. Sessions are delivered by healthcare professionals trained in yoga therapy and combine adapted postures, breathing techniques, and meditative practices. A secure digital platform provides videos, audio materials, questionnaires, support for independent practice, and pseudonymised monitoring of session opening, initiation, interruption, completion, validation, frequency, and regularity.

Primary outcomes

  1. Change in endometriosis-related pain measured by the EHP-30 pain subscale

    Time frame: baseline3 Months6 monthes12 months after surgery

    Between-group difference in change from the preoperative baseline in the pain subscale of the Endometriosis Health Profile-30 (EHP-30), comparing perioperative yoga therapy plus standard surgery with standard surgery alone. The sample-size calculation is based on detecting an additional clinically relevant 11-point reduction in the EHP-30 pain subscore.

Secondary outcomes

  1. Endometriosis-specific and generic health-related quality of life

    Time frame: baseline3 months6 months12 months after surgery

    Changes in the non-pain EHP-30 domains (control and powerlessness, emotional well-being, social support, and self-esteem) and in EQ-5D-5L dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression). A subjective quality-of-life assessment is also recorded in the self-care book.

  2. Pain characteristics, fatigue, sleep, emotional symptoms, sexual health, kinesiophobia, and daily functioning

    Time frame: baseline3 months6 months12 months after surgery. 14 days before each study visit

    Pain intensity and sensory/affective characteristics are assessed using a 0-10 visual analogue scale and the short-form Saint-Antoine Pain Questionnaire. Anxiety and depressive symptoms are assessed with the Hospital Anxiety and Depression Scale. General health observations document sleep, fatigue, urinary and digestive symptoms, emotions, and bodily sensations. Sexual health, fear of movement, and limitations in activities of daily living are also evaluated.

  3. Medication use, healthcare utilisation, hospitalisations, and work absenteeism

    Time frame: baseline3 months6 months12 months after surgery. 14 days before each study visit

    Between-group comparison of medication use, healthcare contacts and consultations, hospital admissions, sick leave, and absence from work over the 12-month follow-up period.

  4. Adherence, acceptability, satisfaction, and autonomous use of the digital platform

    Time frame: During the 16 preoperative and 16 postoperative guided sessions3 to 9 months after surgery

    Attendance at guided sessions, satisfaction with the programme, autonomy, and appropriation of the tools are evaluated. Pseudonymised platform metrics include opening, initiation, interruption, completion and validation of sessions, together with the frequency and regularity of independent practice.

Study contacts

Contact information is provided by the study sponsor or research team.

RUBOD Chrystele Rubod Chrystele, PU-PH

CONTACT

[email protected]

03 20 43 11 24

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Official study title

The Effectiveness of Yoga Therapy on Chronic Pain, Endometriosis Symptoms and Quality of Life Following Surgery for Endometriosis

Acronym: YOGENDOCHIR

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
Aug 14, 2026
Registry last updated
Sep 21, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.